Table 1.
Clinicopathological features of patients with stage III colon cancer
| Total (N = 12904) | Tumor deposits (TDs) | ||||
|---|---|---|---|---|---|
|
| |||||
| TDs- (n = 10884) | TDs ≤ 4 (n = 1766) | TDs > 4 (n = 254) | P-value | ||
| Sex | 0.328 | ||||
| Male | 6270 (48.59%) | 5311 (48.80%) | 846 (47.90%) | 113 (44.49%) | |
| Female | 6634 (51.41%) | 5573 (51.20%) | 920 (52.10%) | 141 (55.51%) | |
| Age | 0.19 | ||||
| < 65 | 6725 (52.12%) | 5687 (52.25%) | 895 (50.68%) | 143 (56.30%) | |
| ≥ 65 | 6179 (47.88%) | 5197 (47.75%) | 871 (49.32%) | 111 (43.70%) | |
| Race | 0.353 | ||||
| White | 9550 (74.01%) | 8028 (73.76%) | 1328 (75.20%) | 194 (76.38%) | |
| AmericanIndian/Alaska Native | 116 (0.9%) | 97 (0.89%) | 15 (0.85%) | 4 (1.57%) | |
| Black | 1916 (14.85%) | 1620 (14.88%) | 265 (15.01%) | 31 (12.20%) | |
| Asian or Pacific Islanders | 1322 (10.24%) | 1139 (10.46%) | 158 (8.95%) | 25 (9.84%) | |
| Primary site | < 0.001 | ||||
| Right colon | 7472 (57.9%) | 6392 (58.73%) | 965 (54.64%) | 115 (45.28%) | |
| Left colon | 5432 (42.1%) | 4492 (41.27%) | 801 (45.36%) | 139 (54.72%) | |
| Pathology | 0.002 | ||||
| Adenocarcinoma | 11551 (89.51%) | 9745 (89.54%) | 1595 (90.32%) | 211 (83.07%) | |
| Mucinous adenocarcinoma | 1186 (9.19%) | 1006 (9.24%) | 145 (8.21%) | 35 (13.78%) | |
| Signet ring cell carcinoma | 167 (1.29%) | 133 (1.22%) | 26 (1.47%) | 8 (3.15%) | |
| Degree of differentiation | < 0.001 | ||||
| Well | 642 (4.98%) | 566 (5.20%) | 68 (3.85%) | 8 (3.15%) | |
| Moderately | 9217 (71.43%) | 7778 (71.46%) | 1285 (72.76%) | 154 (60.63%) | |
| Poorly | 2534 (19.64%) | 2120 (19.48%) | 334 (18.91%) | 80 (31.50%) | |
| Undifferentiated | 511 (3.96%) | 420 (3.86%) | 79 (4.47%) | 12 (4.72%) | |
| pT stage | < 0.001 | ||||
| T1 | 495 (3.84%) | 473 (4.35%) | 20 (1.13%) | 2 (0.79%) | |
| T2 | 1229 (9.52%) | 1116 (10.25%) | 108 (6.12%) | 5 (1.97%) | |
| T3 | 8450 (65.48%) | 7181 (65.98%) | 1133 (64.16%) | 136 (53.54%) | |
| T4 | 2730 (21.16%) | 2114 (19.42%) | 505 (28.60%) | 111 (43.70%) | |
| pN stage | < 0.001 | ||||
| N1a | 4198 (32.53%) | 3842 (35.30%) | 335 (18.97%) | 21 (8.27%) | |
| N1b | 4095 (31.73%) | 3625 (33.31%) | 422 (23.90%) | 48 (18.90%) | |
| N1c | 474 (3.67%) | 0 (0.00%) | 447 (25.31%) | 27 (10.63%) | |
| N2a | 2416 (18.72%) | 2048 (18.82%) | 309 (17.50%) | 59 (23.23%) | |
| N2b | 1721 (13.34%) | 1369 (12.58%) | 253 (14.33%) | 99 (38.98%) | |
| Tumor size(cm) | 0.187 | ||||
| < 5 | 7264 (56.29%) | 6153 (56.53%) | 981 (55.55%) | 130 (51.18%) | |
| ≥ 5 | 5640 (43.71%) | 4731 (43.47%) | 785 (44.45%) | 124 (48.82%) | |
| CEA | < 0.001 | ||||
| Negative | 7637 (59.18%) | 6526 (59.96%) | 984 (55.72%) | 127 (50.00%) | |
| Positive | 5267 (40.82%) | 4358 (40.04%) | 782 (44.28%) | 127 (50.00%) | |
| Nerve invasion | < 0.001 | ||||
| No | 10821 (83.86%) | 9323 (85.66%) | 1343 (76.05%) | 155 (61.02%) | |
| Yes | 2083 (16.14%) | 1561 (14.34%) | 423 (23.95%) | 99 (38.98%) | |
| Chemotherapy | 0.644 | ||||
| No/Unknown | 2969 (23.01%) | 2488 (22.86%) | 420 (23.78%) | 61 (24.02%) | |
| Yes | 9935 (76.99%) | 8396 (77.14%) | 1346 (76.22%) | 193 (75.98%) | |