Table 2.

Univariate and multivariate Cox regression analysis of overall survival rate of patients with stage III colon cancer

	Univariate analysis			Multivariate analysis
	H.R.	95% CI	P-value	H.R.	95% CI	P-value
Sex
Male	1
Female	1.16	1.09, 1.23	< 0.0001	1.32	1.22, 1.43	< 0.0001
Age
< 65	1
≥ 65	1.84	1.73, 1.95	< 0.0001	1.90	1.75, 2.06	< 0.0001
Race
White	1
American Indian/Alaska Native	0.93	0.67, 1.29	0.6695	0.97	0.63, 1.50	0.9034
Black	1.26	1.16, 1.36	< 0.0001	1.44	1.29, 1.61	< 0.0001
Asian or Pacific Islanders	0.88	0.79, 0.97	0.0137	0.84	0.74, 0.97	0.0141
Primary site
Right colon	1
Left colon	0.72	0.68, 0.77	< 0.0001	0.79	0.73, 0.86	< 0.0001
Pathology
Adenocarcinoma	1
Mucinous adenocarcinoma	1.21	1.09, 1.33	0.0002	1.08	0.94, 1.23	0.2915
Signet ring cell carcinoma	3.12	2.58, 3.76	< 0.0001	2.46	1.72, 3.52	< 0.0001
Degree of differentiation
Well	1
Moderately	1.15	0.99, 1.34	0.072	1.07	0.89, 1.30	0.4765
Poorly	1.69	1.45, 1.99	< 0.0001	1.24	1.01, 1.53	0.0383
Undifferentiated	2.06	1.70, 2.50	< 0.0001	1.39	1.07, 1.82	0.0152
pT stage
T1	1
T2	1.26	0.98, 1.62	0.0762	1.15	0.86, 1.53	0.355
T3	2.17	1.74, 2.71	< 0.0001	1.82	1.40, 2.35	< 0.0001
T4	4.06	3.24, 5.09	< 0.0001	3.40	2.60, 4.44	< 0.0001
pN stage
N1a	1
N1b	1.31	1.21, 1.42	< 0.0001	1.36	1.23, 1.51	< 0.0001
N1c	1.41	1.19, 1.67	< 0.0001	0.94	0.74, 1.21	0.6483
N2a	1.66	1.52, 1.81	< 0.0001	1.71	1.52, 1.92	< 0.0001
N2b	2.54	2.32, 2.78	< 0.0001	2.62	2.30, 2.98	< 0.0001
Tumor size (cm)
< 5	1
≥ 5	1.25	1.18, 1.33	< 0.0001	0.94	0.86, 1.02	0.1221
CEA
Negative	1
Positive	1.64	1.55, 1.74	< 0.0001	1.53	1.41, 1.66	< 0.0001
Nerve invasion
no	1
yes	1.53	1.42, 1.65	< 0.0001	1.27	1.14, 1.41	< 0.0001
Tumor deposits
No	1
≤ 4	1.37	1.26, 1.48	< 0.0001	1.24	1.10, 1.41	0.0007
> 4	2.67	2.28, 3.14	< 0.0001	2.48	1.87, 3.29	< 0.0001
Chemotherapy
No/Unknown	1
Yes	0.45	0.42, 0.47	< 0.0001	0.40	0.37, 0.44	< 0.0001