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. 2023 Aug 11;15(44):50638–50651. doi: 10.1021/acsami.3c04245

Figure 1.

Figure 1

Screening and fundamental characterization of the collagen type I hydrogels. (A) A rheological assessment: the hydrogels’ storage modulus (G′) increases with final collagen concentration at stoichiometric amounts of the cross-linker. G′′ < G′ confirms the gel-like properties. (B) The biodegradation profile of the 3 and 5 mg/mL hydrogels in the presence of different concentrations of collagenase type IV. See the key below the graphs for details about the data. (C) An in vitro assessment of the SDF1 release profile for the 5 mg collagen/mL hydrogel. Hydrogels were incubated with 25 ng/mL collagenase for 120 h. (D) An in vitro assessment of the cytotoxicity of the 5 mg collagen/mL hydrogel over HL1 cardiac cells and ADSC. The fold changes in the metabolic activity of the cells that were cultured in the presence of the CH versus those cultured without CH are represented. A noncytotoxic profile was confirmed after 72 and 168 h of incubation, as no significant differences were found between the cells cultured with CH and those cultured without CH. The data are represented as mean ± SEM (N = 3).