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. 2023 Aug 21;3(6):600–619. doi: 10.1021/acsmaterialsau.3c00032

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© 2023 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Chemical structures of various components used in LNP formulations. These include phospholipids (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), and phosphatidylinositol), cholesterol, cationic and ionizable lipids (1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), (1,2-dilinoleyloxy-3-dimethylaminopropane) (Dlin-MC3-DMA)), and PEG lipids (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)](DSPE-PEG), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[succinyl(polyethylene glycol)] (DSG-PEG)).