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. 2023 Nov 10;42:297. doi: 10.1186/s13046-023-02870-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — CXCR7 correlates with the gene signature of the Hippo pathway in gastric cancer. A TCGA data analysis showed that the CXCR7 expression level correlated with poor survival in gastric cancer patients. B GSEA of TCGA data showed a significant positive correlation between CXCR7 and the YAP target gene signature (https://tcga-data.nci.nih.gov). C TCGA database analysis showed a significant positive correlation between the expression levels of CXCR7 and Hippo pathway target genes in gastric cancer samples. D RNA-seq data analysis indicated the top 10 KEGG pathways enriched by CXCR7 depletion in MGC803 cells. Threshold P < 0.05. E GSEA showed that CXCR7 depletion in MGC803 cells decreased the expression of the YAP target gene signature. F Volcano plot showing that CXCR7 depletion inhibits the expression of Hippo pathway signature genes (red) in MCG803 cells. Threshold criteria: P < 0.05 and fold change > 1.5. G Heatmap of YAP target genes in RNA-seq data from MGC803 cell lines treated with siControl or siCXCR7. H Immunohistochemical analysis of gastric cancer samples showed a positive correlation between CXCR7 and YAP (P < 0.001). I The correlation analysis revealed that CXCR7 expression correlated with lymph node metastasis and advanced tumour stage (P = 0.0434 and P = 0.0109, respectively)