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. 2023 Nov 10;42:296. doi: 10.1186/s13046-023-02875-y

Fig. 5.

Fig. 5

Biological function of lncRNA AC016727.1 is mediated by miR-98-5p. a-c miR-98-5p mimics inhibited the proliferation of lncRNA AC016727.1-overexpressing A549 cells. The miR-98-5p inhibitor promoted the proliferation of H1229 cells after lncRNA AC016727.1 knockdown. Quantitative analysis is presented on the right. d miR-98-5p decreased apoptosis in A549 cells overexpressing the lncRNA AC016727.1. After lncRNA AC016727.1 suppression, the miR-98-5p inhibitor increased H1229 cell proliferation. Quantitative analysis is presented on the right. e miR-98-5p mimics attenuated the migratory and invasive properties of A549 cells overexpressing the lncRNA AC016727.1. After lncRNA AC016727.1 knockdown, the miR-98-5p inhibitor increased the migratory and invasive capacities of H1229 cells. Quantitative analysis is presented on the right. f-g. miR-98-5p mimics inhibited the expression of EMT marker proteins in lncRNA AC016727.1-overexpressing A549 cells. The miR-98-5p inhibitor increased H1229 cell EMT marker protein expression after lncRNA AC016727.1 suppression. Quantitative analysis is presented on the right (***p < 0.001, **p < 0.01, and *p < 0.05)

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