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. 2023 Nov 10;42:296. doi: 10.1186/s13046-023-02875-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — miR-98-5p targets BACH1. a Five potential miR-98-5p targets were predicted using TargetScan, ENCORI, and miRDB. b-c Five possible targets' mRNA expression in A549 and H1299 cells following overexpression or knockdown of the lncRNA AC016727.1. d-e Effect of miR-98-5p on BACH1 protein levels. f Sequence alignment of miR-98-5p with BACH1. Binding of miR-98-5p and BACH1 was verified using the per-luciferase reporter assay. g-h The miR-98-5p inhibitor inhibited BACH1 expression in A549 and H1299 cells after lncRNA AC016727.1 knockdown. miR-98-5p mimics increased BACH1 expression in H226 and H173 cells overexpressing the lncRNA AC016727.1. Quantitative analysis is presented on the right. i Relative BACH1 expression in NSCLC and paired paraneoplastic tissues (n = 94). j Relative correlation between the expression of miR-98-5p and BACH1 in NSCLC tissues (n = 94). k Relative correlation between the expression of lncRNA AC016727.1 and BACH1 in NSCLC tissues (n = 94) (***p < 0.001, **p < 0.01, and *p < 0.05)