Table 3.
Impact on fertility from reconstructive surgery or proctectomy after colectomy in women with IBD.
| UC | CD | IBD-U | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Unadjusted | |||||||||
| Colectomy only | 1.00 | 1.00 | 1.00 | ||||||
| IRA | 0.89 | 0.66–1.21 | 0.472 | 1.21 | 0.81–1.83 | 0.355 | 0.83 | 0.66–1.04 | <0.001 |
| IPAA | 0.64 | 0.49–0.84 | 0.002 | N/A | 0.79 | 0.62–1.01 | <0.001 | ||
| Proctectomy | 0.61 | 0.48–0.78 | <0.001 | 0.70 | 0.45–1.10 | 1.121 | 0.63 | 0.51–0.78 | <0.001 |
| Adjusted for age at disease onset, year of colectomy and parity at colectomy | |||||||||
| Colectomy only | 1.00 | 1.00 | 1.00 | ||||||
| IRA | 0.86 | 0.63–1.17 | 0.329 | 1.07 | 0.70–1.63 | 0.772 | 0.86 | 0.68–1.08 | 0.196 |
| IPAA | 0.67 | 0.50–0.88 | 0.005 | N/A | 0.85 | 0.66–1.08 | 0.081 | ||
| Proctectomy | 0.65 | 0.49–0.85 | 0.002 | 0.61 | 0.38–0.96 | 0.032 | 0.68 | 0.55–0.85 | 0.001 |
Ulcerative colitis [UC], Crohn’s disease [CD], inflammatory bowel disease unclassified [IBD-U]. Ileoanal pouch anastomosis [IPAA], ileorectal anastomosis [IRA]. Hazard ratio [HR] with 95% confidence interval [95% CI].