Table 5.
Impact of colectomy with or without subsequent reconstructive surgery or proctectomy on male fertility for IBD subtypes, expressed as hazard ratio for partner giving birth compared with matched individuals from the general population.
| IBD-cohort | IBD-subcohorts | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UC | CD | IBD-U | ||||||||||||||
| No. | HR | 95% CI | p-value | No. | HR | 95% CI | p-value | No. | HR | 95% CI | p-value | No. | HR | 95% CI | p-value | |
| Colectomy only | 885 | 0.85 | 0.77–0.94 | 0.002 | 417 | 0.94 | 0.81–1.10 | 0.435 | 82 | 0.75 | 0.56–1.00 | 0.054 | 386 | 0.81 | 0.69–0.94 | 0.005 |
| IRA | 699 | 0.88 | 0.78–0.98 | 0.026 | 299 | 0.95 | 0.79–1.15 | 0.625 | 92 | 0.85 | 0.65–1.11 | 0.227 | 308 | 0.83 | 0.70–0.99 | 0.038 |
| IPAA | 976 | 0.88 | 0.80–0.96 | 0.006 | 559 | 0.85 | 0.75–0.96 | 0.011 | 2 | 1.43 | 0.29–7.11 | 0.664 | 375 | 0.91 | 0.79–1.05 | 0.186 |
| Proctectomy | 1,251 | 0.91 | 0.84–0.98 | 0.012 | 575 | 0.93 | 0.83–1.04 | 0.217 | 145 | 0.77 | 0.62–0.97 | 0.024 | 531 | 0.93 | 0.83–1.03 | 0.178 |
Inflammatory bowel disease [IBD], ulcerative colitis [UC], Crohn’s disease [CD], IBD unclassified [IBD-U]. Hazard ratio [HR] with 95% confidence interval [95% CI].