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. 2023 Sep 15;114(11):4459–4474. doi: 10.1111/cas.15942

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© 2023 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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CIBERSORTx estimation of immune cell infiltration. (A) The CIBERSORTx estimated absolute cell fractions of 22 leukocyte types in each sample using microarray data. (B) The total estimated absolute cell fractions in each sample were compared among the three groups. Totals of the estimated infiltrated leukocyte fractions were significantly increased in both the highly resistant and sensitive groups relative to the non‐tumor samples. (C) Estimated fractions of each leukocyte type were compared among the three groups. Immune cell types showing significant difference between fractions of the highly resistant and sensitive groups were indicated by red. The estimated M1 macrophage fraction showed the most significant difference between the highly resistant and sensitive groups. Significance was expressed using Steel–Dwass test. p‐values of less than 0.05 were considered significant and are indicated.