FIGURE 4.

Expression of CXCL9 mRNA by microarray and RNAScope in situ hybridization. (A) Normalized values of CXCL9 mRNA expression by microarray analysis. Cases subjected to RNAScope in situ hybridization in (B) are indicated by bold numbers. (B) Distribution of CXCL9 mRNA in the selected sensitive (cases 11 and 33) and highly resistant (cases 20 and 25) cases were investigated by RNAScope in situ hybridization. Sensitive cases showed high expression of CXCL9 mRNA. (C) High‐power views of images in (B). Tumor islets in (C) are indicated in Figure S3.