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. 2023 Sep 3;114(11):4225–4236. doi: 10.1111/cas.15944

FIGURE 6.

FIGURE 6

B7H3− prostaglandin‐endoperoxide synthase 2 (PTGS2)+ sterol regulatory element binding protein 2 (SREBP2)+ cells promote an improved prognosis in colorectal cancer (CRC) patients. (A, B) Representative images of multiplex immunohistochemistry assay of B7H3 (red), PTGS2 (green), and SREBP2 (orange) expression in (A) CRC tumor tissue and (B) adjacent normal tissue. Nuclei and tumor epithelial cells are marked by DAPI (blue) and cytokeratin (CK; yellow), respectively. Scale bar, 50 μm. (C) Percentages of B7H3+ cells in tumor tissues (n = 89) and normal tissues (n = 84). (D) Kaplan–Meier analysis of the survival rate of 89 CRC patients stratified according to the B7H3+ cells level. (E) Percentages of B7H3− PTGS2+SREBP2+ cells in tumor tissues (n = 89) and normal tissues (n = 84). (F) Kaplan–Meier analysis of the survival rate of 89 CRC patients stratified into B7H3− PTGS2+SREBP2+ cells low (proportion ≤ median value) and B7H3− PTGS2+SREBP2+ cells high (proportion > median value)groups. Results are presented as mean ± SD. **p < 0.01, ****p < 0.0001.