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. 2023 Nov 9;38:15333175231214861. doi: 10.1177/15333175231214861

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© The Author(s) 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Increased expression of the KP enzymes and AhR activation in the hippocampus of AD mice. A. mRNA expressions of KP enzymes quantified by qPCR. (n ≥ 6 mice in each group). (B and C) Expressions of IDO1 and AhR proteins determined by western blot. (n ≥ 5 mice in each group). WT^APOE−/− and APOE−/−: male mice at 3 months of age. WT^APP/PS1 and APP/PS1: male mice at 6 months of age. (D and E) mRNA expression of CYP1A1 quantified by qPCR. (n ≥ 3 mice in each group). All data were analyzed by Student’s t test and expressed as the mean ± SEM, *P < .05, **P < .01. The mRNA expression levels are normalized to the level of Actb mRNA.