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. 2023 Nov 9;38:15333175231214861. doi: 10.1177/15333175231214861

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© The Author(s) 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Application of IDO1 inhibitor changed the expression pattern of inflammatory cytokines and neurotrophic factors in the hippocampus of APP/PS1 mice (8-month-old, male). (A) mRNA expressions of IFN-γ, TNF-α, IL-1β and IL-10 in the hippocampus quantified by qPCR. (B) mRNA expressions of BDNF, NGF and GDNF in the hippocampus quantified by qPCR. The mRNA values are normalized to the level of Actb mRNA. (n = 6-7 mice in each group). (C) Expression of BDNF protein in the hippocampus determined by western blot. (n = 6-7 mice in each group). All data were analyzed by one-way ANOVA followed by Dunnett’s post hoc test and expressed as the mean ± SEM. *P < .05, **P < .01.