Table 2.

Efficacy According to Different Early CRP Kinetics

	Flare-Responder N=29	Responder N=45	Non-Responder N=58	p value
Overall survival
Median (95% CI), months	–	20.6 (15.5–25.7)	10.0 (3.1–16.9)	<0.001
Progression-free survival
Median (95% CI), months	11.6 (7.5–15.7)	5.2 (2.3–8.1)	2.3 (1.1–3.6)	<0.001
Best radiological response
CR	3 (10.3%)	1(2.2%)	0 (0.0%)
PR	9 (31.1%)	5(11.1%)	2 (3.5%)
PD	6 (20.7%)	14 (31.1%)	30 (51.7%)
SD	11 (37.9%)	25 (55.6%)	26 (44.8%)
ORR (CR+PR)	12 (41.4%)	6(13.3%)	2 (3.5%)	<0.001
DCR (CR+PR+SD)	23 (79.3%)	31 (68.9%)	28 (48.3%)	<0.001

Abbreviations: CI, confidence interval; CR, complete response; PR, partial response; PD, progressive disease; SD, stable disease; ORR, objective response rate; DCR, disease control rate.