Table 4.
Univariable and Multivariable Cox Regression Analyses of Risk Factors for Overall Survival
| Univariable HR (95% CI) |
p value | Multivariable HR (95% CI) |
p value | |
|---|---|---|---|---|
| Gender | ||||
| Male | – |
0.32 |
||
| Female | 1.54 (0.66–3.62) | |||
| Age, y | ||||
| ≤60 | – |
0.50 |
||
| >60 | 1.27 (0.64–2.51) | |||
| Child-Pugh grade | ||||
| A | – |
0.56 |
||
| B | 1.23 (0.61–2.51) | |||
| BCLC stage | ||||
| B | – |
0.65 |
||
| C | 1.16 (0.62–2.15) | |||
| ECOG PS | ||||
| 0 | – |
0.46 |
||
| ≥1 | 1.24 (0.70–2.21) | |||
| Tumor size (cm) | ||||
| ≤5 | – |
0.78 |
||
| >5 | 1.08 (0.62–1.90) | |||
| CRP level | ||||
| ≤5 mg/dl | – |
0.23 |
||
| >5 mg/dl | 1.40 (0.80–2.44) | |||
| AFP level | ||||
| ≤400 ng/mL | – |
0.04 |
– |
0.04 |
| >400 ng/mL | 1.71 (1.00–2.91) | 1.71 (1.00–2.91) | ||
| NLR | ||||
| <3 | – |
0.32 |
||
| ≥3 | 1.30 (0.77–2.17) | |||
| Early CRP kinetics | ||||
| Non-responder | – | – | ||
| Responder | 0.57 (0.33–0.97) | 0.04 | 0.55 (0.32–0.94) | 0.03 |
| Flare-responder | 0.12 (0.04–0.34) | <0.001 | 0.12 (0.04–0.33) | <0.001 |
Abbreviations: BCLC stage, Barcelona Clinic Liver Cancer stage; ECOG PS, Eastern Cooperative Oncology Group performance status; CRP, C-reactive protein; AFP, a-fetoprotein; NLR, Neutrophil-lymphocyte ratio; HR, hazard ratio; CI, confidence interval.