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. 2014 Mar 3;2014(3):CD010813. doi: 10.1002/14651858.CD010813.pub2

van Hylckama Vlieg 2009.

Methods case control study
Participants 1999‐2004
1,525 cases / 1,760 controls (community based)
age: <50 y
diagnosis: anticoagulation
Interventions 1st, 2nd and 3rd generation
Outcomes Events during 1st generation 55 / 81; 2nd generation 382 / 672; 3rd generation 412 / 582. Non‐use 421 / 1,523.
Adjustment for confounding: yes
Notes The Netherlands