FIGURE 5.

Low-dose AraC induces expression of differentiation-associated genes together with activation of cytokine and chemokine signaling pathways and stromal co-culture inhibits these effects. (A) Volcano plots presenting differentially expressed genes in U937 cells treated with AraC (100 nM) for 24 h with or without co-culture with MS-5 stromal cells. (B,C) Enriched Gene ontology (GO) pathways associated with biological processes (BP) and molecular functions (MF) in U937 cells treated with AraC (100 nM) for 24 h with or without co-culture with stromal MS-5 cells. Presented values are |log(padj)| in enrichment analysis. Upregulated pathways are presented as positive, while downregulated pathways are presented as negative values.