Table 2.
Proteins associated with sickle cell trait status in Women's Health Initiative Black participants
| Name | Uniprot ID | Protein | β | SEM | P Value |
|---|---|---|---|---|---|
| CX3CL1 | P78423 | Fractalkine | 0.3875 | 0.0565 | 1.14E-11 |
| HAVCR1 | Q96D42 | Hepatitis A virus cellular receptor 1 (KIM-1) | 0.3723 | 0.0553 | 2.58E-11 |
| HMOX1 | P09601 | Heme oxygenase-1 | 0.3695 | 0.0568 | 1.16E-10 |
| TGFBR2 | P37173 | TGF-β receptor type-2 | 0.3076 | 0.0560 | 4.71E-08 |
| EPHB4 | P54760 | Ephrin type-B receptor 4 | 0.3043 | 0.0567 | 9.54E-08 |
| IL10RB | Q08334 | Interleukin-10 receptor subunit β | 0.3017 | 0.0568 | 1.31E-07 |
| AHSP | Q9NZD4 | AHSP | 0.3001 | 0.0573 | 1.96E-07 |
| MMP7 | P09237 | Matrilysin | 0.2898 | 0.0567 | 3.67E-07 |
| CCL2 | P13500 | C-C motif chemokine 2 | 0.2921 | 0.0571 | 3.73E-07 |
| PLAUR | Q03405 | Urokinase plasminogen activator surface receptor | 0.2810 | 0.0562 | 6.73E-07 |
| WFDC2 | Q14508 | WAP four-disulfide core domain protein 2 | 0.2585 | 0.0524 | 9.42E-07 |
| TNFRSF4 | P43489 | TNF receptor superfamily member 4 (OX40) | 0.2801 | 0.0569 | 9.71E-07 |
| EPO | P01588 | Erythropoietin | 0.2803 | 0.0578 | 1.40E-06 |
| SCARB2 | Q14108 | Lysosome membrane protein 2 | 0.2643 | 0.0551 | 1.84E-06 |
| B4GALT1 | P15291 | β-1,4-galactosyltransferase 1 | 0.2699 | 0.0569 | 2.38E-06 |
| DLL1 | O00548 | Delta-like protein 1 | 0.2640 | 0.0565 | 3.30E-06 |
| EFNA4 | P52798 | Ephrin-A4 | 0.2594 | 0.0558 | 3.76E-06 |
| NECTIN4 | Q96NY8 | Nectin-4 | 0.2624 | 0.0565 | 3.84E-06 |
| SPON2 | Q9BUD6 | Spondin-2 | 0.2590 | 0.0564 | 4.90E-06 |
| GDF15 | Q99988 | Growth/differentiation factor 15 | 0.2352 | 0.0514 | 5.15E-06 |
| STC1 | P52823 | Stanniocalcin-1 | 0.2606 | 0.0572 | 5.78E-06 |
| COLEC12 | Q5KU26 | Collectin-12 | 0.2448 | 0.0550 | 9.43E-06 |
| AMBP | P02760 | A1M | 0.2518 | 0.0567 | 9.72E-06 |
| SIRPB1 | O00241 | Signal-regulatory protein β-1 | 0.2520 | 0.0571 | 1.11E-05 |
| CD79B | P40259 | B-cell antigen receptor complex-associated protein β chain | 0.2502 | 0.0569 | 1.20E-05 |
| EPHA2 | P29317 | Ephrin type-A receptor 2 | 0.2434 | 0.0556 | 1.29E-05 |
| IGFBP4 | P22692 | Insulin-like growth factor-binding protein 4 | 0.2405 | 0.0554 | 1.52E-05 |
| AGRP | O00253 | Agouti-related protein | 0.2455 | 0.0573 | 1.96E-05 |
| FAS | P25445 | TNF receptor superfamily member 6 (FAS) | 0.2420 | 0.0565 | 1.99E-05 |
| TNFRSF21 | O75509 | TNF receptor superfamily member 21 (DR6) | 0.2438 | 0.0570 | 2.06E-05 |
| UMOD | P07911 | Uromodulin | −0.2394 | 0.0564 | 2.34E-05 |
| THY1 | P04216 | Thy-1 membrane glycoprotein | 0.2414 | 0.0570 | 2.44E-05 |
| FCER2 | P06734 | Low-affinity immunoglobulin epsilon Fc receptor | 0.2430 | 0.0575 | 2.52E-05 |
| CKAP4 | Q07065 | Cytoskeleton-associated protein 4 | 0.2342 | 0.0558 | 2.91E-05 |
| FOLR1 | P15328 | Folate receptor α | 0.2342 | 0.0562 | 3.25E-05 |
The β coefficient for sickle cell trait association is measured on the one-SD change scale (for rank-based inverse normal transformed protein expression values). AHSP, α-hemoglobin–stabilizing protein; A1M, α-1 microglobulin.