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. 2023 Nov 10;102(45):e35852. doi: 10.1097/MD.0000000000035852

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Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — PPI network and core genes of esculetin against UC. (A) PPI network of the potential action targets of esculetin against UC, darker colors, larger fonts, and larger shapes of genes indicate higher betweenness, closeness, and degree values. The 10 genes in the center are the core genes. (B) Betweenness, closeness, and degree values of core genes including AKT1, STAT1, CCND1, SRC, PTGS2, EGFR, NFKB1, ESR1, MMP9, and SERPINE1. (C) PPI network of the 10 core genes, line thickness indicates the strength of data support. UC = ulcerative colitis, PPI = protein–protein interaction.