Table 5.
Univariate and multivariate Cox regression analysis of the associations between patient characteristics and overall survival.
| Risk factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Male sex | 1.38 | 0.47–3.99 | .551 | – | – | – |
| Age ≥ 65 years | 0.94 | 0.46–1.92 | .861 | – | – | – |
| Viral hepatitis | 0.91 | 0.51–2.15 | .912 | – | – | – |
| ECOG-PS ≥ 1 | 3.54 | 1.65–7.61 | .001 | 2.69 | 1.16–6.20 | .020 |
| AFP ≥ 200 ng/mL | 1.57 | 0.74–3.32 | .236 | – | – | – |
| Child-Pugh class B | 3.04 | 1.21–7.62 | .018 | 1.28 | 0.47–3.53 | .628 |
| NLR > 2.9 | 3.04 | 1.30–7.12 | .010 | 2.94 | 1.21–7.15 | .017 |
| Extrahepatic spread | 1.50 | 0.72–3.13 | .279 | – | – | – |
| Antibiotic use* | 3.64 | 1.52–8.7 | .004 | 4.18 | 1.65–10.57 | .003 |
Bold values indicate statistical significance.
AFP = alpha-fetoprotein, CI = confidence interval, ECOG-PS = Eastern Cooperative Oncology Group-Performance Status, HR = hazard ratio, NLR = neutrophil-to-lymphocyte ratio.
*
Concurrent use of antibiotics with immunotherapy.