TABLE 2.

Fractions of copper associated with different chelators when they were mixed with a Cu-saturated POI solution^a

Chelator	Cu-ligand association constant (log K1)	% of total Cu in ligand
TRIEN	20.4b	76.6
EDTA	18.8c	68.3
DEN (DEN/Cu ratio, 2:1)	16.0c	81.2
DEN (DEN/Cu ratio, 1:1)	16.0c	34.0
DEN (DEN/Cu ratio, 0.5:1)	16.0c	24.3
NTA	13.1c	20.5
EN	10.5b	3.7
Tryptophan	8.3c	14.4
IDA	5.6d	20.6

^aA molar ratio of chelator to Cu in the POI of approximately 1:1 was used in the experiments unless otherwise otherwise noted. 

^bData from reference 12. 

^cData from reference 20. 

^dData from reference 4.