Skip to main content
. 2023 Nov 10;18(11):e0294249. doi: 10.1371/journal.pone.0294249

Fig 1. Iberiotoxin-sensitive BKβ1 is involved in E2-induced colonic SMC relaxation.

Fig 1

A Contractile activity of colonic SMC in each group (n = 6 each). B Detection of the maximal contraction after Ach stimulation. *P < 0.05 when compared with C, BSA-E2 and E2+EI groups. C Representative trace showing that E2 (1 μmol/l) inhibits rat colonic SMC contractions. Preincubation with Iberiotoxin (IBTX, 1 μmol/l), a BKβ1 blocker, partially reversed the contractile E2-induced inhibition (n = 6 each). D Results are presented as a percentage, which is expressed as the ratio of the contraction amplitude of smooth muscles after DMSO or estrogen treatment to the maximum value of ACH-induced contraction. All data are displayed as mean ± SEM. *P < 0.05 and **P < 0.01.