Appendix 3—table 3. Covariate description.
| Covariate description | Variable name | Covariate values | Additional details |
|---|---|---|---|
| Race/ethnicity including Asian | der_race_v2 | Hispanic; Non-Hispanic AAPI; Non-Hispanic Black; Non-Hispanic White; Other | |
| Age with imputation for categoricals | der_age_trunc | Years (continuous 18–89; patients noted to be greater than 89 are set to be age = 90) | |
| Insurance type | der_insurance | Medicaid alone; Medicare alone; Medicare/Medicaid ± other; Other government ± other; Private ± other; Uninsured; Unknown | |
| Derived variable for smoking status collapsing the current/former smoker variables | der_smoking2 | Never; Current or Former; Unknown | |
| Binary obesity (BMI ≥ 30 or checkbox checked) indicator | der_obesity | 0=No; 1=Yes; 99=Unknown | |
| Cardiovascular comorbidity (CAD, CHF, Afib, arrhythmia NOS, PVD, CVA, cardiac disease NOS) | der_card | 0=No; 1=Yes; 99=Unknown | |
| Derived variable indicating whether patient has pulmonary comorbidities | der_pulm | 0=No; 1=Yes; 99=Unknown | |
| Renal comorbidities | der_renal | 0=No; 1=Yes; 99=Unknown | |
| Derived variable indicating whether patient has diabetes mellitus | der_dm2 | 0=No; 1=Yes; 99=Unknown | |
| Performance status | der_ecogcat2 | ECOG 0, 1, or 2+ | |
| Breast biomarkers combined variable | der_breast_biomarkers | 1=ER + ; 2=ER + /HER2+; 3=HER2+; 4=triple negative; 99=Unknown | |
|
Derived variable indicating cancer status (splits remission/NED by cancer timing) |
der_cancer_status_v4 | 0 - Remission/NED, remote; 1 - Remission/NED, recent; 2 - Active, responding; 3 - Active, stable; 4 - Active, progressing; 99 - Unknown | |
| Timing of cancer treatment relative to COVID-19, collapsed | der_cancer_tx_timing_v2 | 0=more than 3 months; 1=0–4 weeks; 2=1–3 months (*); 88=never or after COVID-19 diagnosis; 99=unknown | |
| No cancer treatment in the 3 months prior to COVID-19 | der_cancertr_none | 0=No; 1=Yes; 99=Unknown | Derived with the following covariates: der_any_cyto, der_any_targeted, der_any_endo, der_any_immuno, der_any_local, der_any_other Coded as 1 if all these variables are 0; coded as 0 if any of these variables is 1; coded as 99 if any of these variables is 99; otherwise, NA |
| Any cytotoxic cancer treatment in the 3 months prior to COVID-19 | der_any_cyto | 0=No; 1=Yes; 99=Unknown | |
| Any targeted therapy in the 3 months prior to COVID-19 | der_any_targeted | 0=No; 1=Yes; 99=Unknown | |
| Any targeted therapy includes an anti-HER2 therapy in the 3 months prior to COVID-19 | der_her2_3 m | 0=No; 1=Yes | Derived with der_her2, der_any_targeted. Coded as 1 if der_any_targeted is 1 and der_her2 is 1 Coded as 0 if: a. der_any_targeted is 1 and der_her2 is 0 der_any_targeted is 1 Otherwise, NA der_her2: 0=No; 1=Yes |
| Any targeted therapy includes a CDK4/6 inhibitor therapy in the 3 months prior to COVID-19 | der_cdk46i_3 m | 0=No; 1=Yes | Derived with der_cdk46i, der_any_targeted. Coded as 1 if der_any_targeted is 1 and der_cdk46i is 1 Coded as 0 if: a. der_any_targeted is 1 and der_cdk46i is 0 der_any_targeted is 1 Otherwise, NA der_cdk46i: 0=No; 1=Yes |
| Any other targeted therapy (not anti-HER2/CDK4/6 inhibitor) in the 3 months prior to COVID-19 | der_other_3 m | 0=No; 1=Yes | Derived with der_targeted_not_her2_cdk46i, der_any_targeted. Coded as 1 if der_any_targeted is 1 and der_targeted_not_her2_cdk46i is 1 Coded as 0 if: a. der_any_targeted is 1 and der_targeted_not_her2_cdk46i is 0 der_any_targeted is 1 Otherwise, NA der_targeted_not_her2_cdk46i: 0=No; 1=Yes |
| Any endocrine therapy in the 3 months prior to COVID-19 | der_any_endo | 0=No; 1=Yes; 99=Unknown | |
| Any immunotherapy in the 3 months prior to COVID-19 | der_any_immuno | 0=No; 1=Yes; 99=Unknown | |
| Any local therapy (surgery or RT) within 3 months | der_any_local | 0=No; 1=Yes; 99=Unknown | |
| Any other cancer therapy in the 3 months prior to COVID-19 | der_any_other | 0=No; 1=Yes; 99=Unknown | |
| Region of patient residence with ex-US collapsed | der_region_v2 | Non-US; Other; Undesignated US; US Midwest; US Northeast; US South; US West | |
| Trimester and year of diagnosis, using the most recent side of the interval as anchor | der_tri_rt_dx | T1 2020; T2 2020; T3 2020; T1 2021 | |
| What type of area does the patient primarily reside in? | urban_rural1 | 1, Urban (city) | 2, Suburban (town, suburbs) | 3, Rural (country) | 88, Other | 99, Unknown | |
| The type of health care center providing the patient’s data | der_site_type | AMC = academic medical center; CP = community practice; TCC = tertiary care center | |
| Initial severity and course of illness | severity_of_covid_19_v21 | 1, Mild (no hospitalization required) | 2, Moderate (hospitalization indicated) | 3, Severe (ICU admission indicated) | 99, Unknown | |
| Derived treatment intent | der_tr_intent | Unknown Treatment; Not on Treatment; Palliative; Curative; Missing Unknown Treatment and Missing were collapsed for analysis |
Derived with der_anytx and treatment_intent: Coded as ‘Unknown Treatment’ if der_anytx is NA or 99; Coded as ‘Not on Treatment’ if der_anytx is 0 Coded as ‘Palliative’ if der_anytx is 1 and treatment_intent is 2 Coded as ‘Curative’ if der_anytx is 1 and treatment_intent is 1 Otherwise, Missing der_anytx: 0=No; 1=Yes; 99=Unknown Treatment_intent: 1, Curative | 2, Palliative | 99, Unclear or unknown |
| Most recent line of cancer treatment, including systemic and non-systemic therapies | der_txline | Untreated in last 12 months; Curative NOS; First line; Non-curative NOS; Other; Second line or greater; Unknown | |
| Hematologic malignancy indicator | der_heme | 0=No; 1=Yes |