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. 2023 Oct 26;15:1281748. doi: 10.3389/fnagi.2023.1281748

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Copyright © 2023 Suh, Lee, Jung, Wen, Bao, Nho, Huang, Davatzikos, Saykin, Thompson, Shen and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PRS, PRS.with.APOE, adORS, and adORS.with.APOE associations with major AD clinical assessments of cognitive functions. Bar plots of Pearson correlations between each risk score (adORS: red, PRS: blue) and cognitive assessments in the entire cohort. Results are shown for the following tasks: CN vs. AD classification (A and B) and MCI conversion prediction (C and D). CNAD, CN vs. AD classification; MCI-CP, MCI conversion prediction; ADAS 13, Alzheimer’s disease assessment scale-cognitive subscale 13; CDRSB, Clinical dementia rating scale-sum of boxes; RAVLT, Rey auditory verbal learning test; MMSE, Mini mental state examination; and FAQ, Functional activities questionnaire.