PubMed Literature Search Strategy
Search Number	Search Terms
Population of interest
#1	'plague'[Mesh] OR 'plague'[Text] OR 'pneumonic plague'[Text] OR ‘pulmonic plague’ [Text] OR 'bubonic plague' [Text] OR ‘bacterial plague’ [Text] OR ‘oriental plague’ [Text] OR ‘yersinia pestis infection’[Text] OR ‘Black death’ [Text] OR ‘Black plague’[Text]
Intervention
#2	'plague vaccine'[Mesh] OR 'plague vaccine'[Text] OR ‘Plague vaccines’[Text] OR ‘plague vaccination’[Text] OR vaccines[Mesh] OR vaccine[Text] OR vaccines[Text] OR vaccination[Text]
Study Design
#3	randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized[title/abstract] OR placebo[title/abstract] OR clinical trials as topic[mesh:noexp] OR randomly[title/abstract] OR trial[title]
Exclusion terms
#4	“Animals”[Mesh] NOT “Humans”[Mesh]
#5	“Comment”[Publication Type] OR “Letter”[Publication Type] OR “Editorial”[Publication Type] OR “Case Reports”[Publication Type] OR case stud*[Title] OR case report*[Title] OR “case series”[Title] OR case histor*[Title]
All relevant studies
#6	#1 AND #2 AND #3
#7	#6 NOT (#4 OR #5)