TABLE 1.

Summary of important transport findings for different platforms

Cell lines	Platform	Finding
MDA-MB-231/TIME	Breast carcinoma	• 70 kDa particle peak intensity was increased by 1.66-fold compared with 3 kDa particle • 3 kDa and 70 kDa peak intensity was increased by 1.39- and 3.65-fold compared with Control− (Tumorigenic) • 70 kDa ECM accumulation rate increased by 5.57-fold compared with 3 kDa particles after passing through the healthy liver • For the metabolized condition, the 3 kDa vessel accumulation rate decreased by 5.49-fold compared with the direct delivery condition
C3Asub28/TIME	Hepatocellular carcinoma	• 70 kDa particle peak intensity was increased by 1.59-fold compared with 3 kDa particle. • 3 and 70 kDa peak intensity was increased by 2.77- and 4.88-fold compared with Control− (Tumorigenic). • 3 and 70 kDa vessel accumulation increased by 1.05- and 3.94-fold, respectively, compared with the standalone condition after passing through breast carcinoma
THLE-3/TIME	Healthy liver	• 70 kDa healthy liver ECM accumulation rate decreased by 2.57-fold compared with 3 kDa particles after passing through breast carcinoma • 3 kDa ECM accumulation rate increased by 2.46-fold after particles passed through the breast carcinoma