Table 1.
Expression patterns of claudins in normal tissues.
| Claudins | Expression patterns | Reference |
|---|---|---|
| CLDN1 | Intestine, brain, kidney, liver, testis, fetal lung alveolar epithelial (HFL) cells, bronchiolar epitheliums, and pancreatic ducts and exocrine glands | [[19], [20], [21]] |
| CLDN2 | Pancreatic ducts and exocrine glands | [21] |
| CLDN3 | Colorectal, thyroid, salivary gland, pancreas, prostate cancer, liver, kidney, HFL cells, bronchiolar epitheliums, pancreatic ducts and exocrine glands, and pancreatic islet endocrine glands | [[19], [20], [21]] |
| CLDN4 | Breast, ovary, prostate, bladder, gastrointestinal mucosa, bile duct, HFL cells, type II alveolar epitheliums, bronchiolar epitheliums, and pancreatic ducts and exocrine glands | [[19], [20], [21]] |
| CLDN5 | HFL cells, type II alveolar epitheliums, and vascular endothelial cells | [20,22,23] |
| CLDN6 | Normal tissues during embryonic development | [24,25] |
| CLDN7 | Bronchiolar epitheliums, pancreatic ducts and exocrine glands, and pancreatic islet endocrine glands | [20,21] |
| CLDN10a | Kidney | [26] |
| CLDN14 | Thick ascending limb of Henle | [27,28] |
| CLDN18.1 | HFL cells and type II alveolar epitheliums | [19] |
| CLDN18.2 | Gastric mucosal epithelial cells | [4] |