. 2023 Oct 29;9(11):e21338. doi: 10.1016/j.heliyon.2023.e21338

Table 2.

Function of claudins in normal tissues.

Claudins	Function	Reference
CLDN2	Formation of cation channels	[29]
	Promotes the permeability of Na⁺ and water through solvent dragging	[30]
CLDN5	Formation of blood-brain barrier	[22]
CLDN10a	Formation of anion channels	[29,31]
CLDN10b	Formation of cation channels	[29,31]
CLDN14	Regulated the permeability of Ca²⁺ in the thick ascending limb of Henle (TAL)	[27,28]
CLDN15	Formation of cation channels	[29]
	Decoupled the solvent dragging effect of CLDN2	[32]
CLDN16	Regulated the permeability of Mg²⁺ in the TAL	[33,34]
CLDN17	Formation of anion channels	[29]
CLDN18.1	Maturation and differentiation of the alveolar epithelium	[3,[35], [36], [37]]
CLDN18.2	Regulated the permeability of H⁺ between gastric mucosal epithelial cells	[38]
	Formation of gastric mucosal barrier	[39]
CLDN19	Regulated the permeability of Mg2+ in the TAL	[34]