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. 2023 Oct 29;9(11):e21338. doi: 10.1016/j.heliyon.2023.e21338

Table 4.

Roles of claudins in pancreatic cancer.

Claudins Activity Findings Reference
CLDN1 Tumor suppressor Promoted apoptosis and inhibited proliferation [15]
CLDN4 Tumor suppressor Inhibited the invasiveness of cancer cells [113]
CLDN7 Tumor promoter Improved the invasion and metastasis, and promoted the resistance to cisplatin [50]
CLDN12 Tumor promoter Promoted EMT [115]
CLDN18.2 Tumor suppressor High expression of CLDN18.2 correlated with a better prognosis [116]