Figure 4.

Dominant factor scores in top component link to RPL and RPS family with subsequent gene enrichment in Ribosome and Coronavirus disease

The perturbations with top factor scores in the first component mostly belong to RPL and RPS family(A), and the enrichment analysis results of downstream genes in the same component are enriched for ribosome and coronavirus disease(B). Each point in (A) represents the latent factor value of each perturbation. The top 9 points as well as the control group are labeled in the plot and colored red and blue, respectively. In gene set enrichment analysis, we input the downstream genes with $\text{PIP}>0.9$ and show the top enriched pathways with log(FDR) and the number of genes included in the corresponding pathways.