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. 2023 Oct 5;31(11):3146–3162. doi: 10.1016/j.ymthe.2023.09.021

Figure 1.

Figure 1

The system of orthogonal IL-2

(A) Schematic of native IL-2R, orthogonal IL-2R, or γc family chimeric orthogonal receptor. (B) Native IL-2 and orthogonal IL-2 can only match their corresponding receptors. (C) Orthogonal IL-2 acts on CAR-T cells armed with orthogonal IL-2R, which promotes the activation and proliferation of the CAR-T cells.