Table 2.

Concentrations of the transgene product (KH631 protein) in different tissues of rhesus monkeys after a single subretinal injection of KH631 in bilateral eyes (ng/g for solid tissues or ng/mL for liquid tissues)

Name	4 wk postdose		8 wk postdose		13 wk postdose
	1F001	1M001	1F002	1M002	1F003	1M003
Cornea	BLQ	BLQ	BLQ	28.6	45.8	60.6
Aqueous humor∗	118	BLQ	198	34.5	87.7	188
Iris/Ciliary body	415	BLQ	369	96.1	314	144
Lens	BLQ	BLQ	BLQ	BLQ	82.8	50.7
Vitreous body∗	651	190	1930	253	580	1190
Retina	15400	26800	22400	10400	17000	13000
Choroid	9370	4330	7330	16400	9910	3850
Sclera	642	255	BLQ	103	769	178
Optic nerve	BLQ	BLQ	BLQ	104	65.4	34.5
Conjunctiva	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ
Liver	25.9	23.7	34.2	60.6	280	224
Spleen	BLQ	BLQ	BLQ	BLQ	42.4	32.8
Feces	BLQ	BLQ	BLQ	BLQ	34.2	55.7
Preauricular Lymph nodes	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ
Lacrima	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ
Bone marrow∗	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ
Cerebrum	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ
Forebrain	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ
Thalamus	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ
Jejunum	BLQ	BLQ	BLQ	BLQ	36.1	49.9
Kidney	BLQ	71.4	64.8	106	349	318
Nasal mucous	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ
Oral mucosa	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ
Skeletal muscle	BLQ	BLQ	BLQ	BLQ	25.8	45.0
Stomach	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ
Pancreas	BLQ	BLQ	BLQ	BLQ	175	189
Heart	BLQ	BLQ	BLQ	BLQ	83.4	62.4
Ovary	BLQ	–	BLQ	–	BLQ	–
Uterus	BLQ	–	BLQ	–	BLQ	–
Epididymis	–	BLQ	–	BLQ	–	BLQ
Prostate gland/Seminal vesicle	–	BLQ	–	BLQ	–	BLQ
Testis	–	BLQ	–	BLQ	–	BLQ
Lung	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ
Urine∗	BLQ	BLQ	BLQ	BLQ	BLQ	BLQ

“∗” means liquid tissues, with the unit of ng/mL; “–” means no tissue; BLQ means below the lower limit of quantification.