Table 4.
Anti-AAV8 neutralizing antibody levels in serum at different time points after a single subretinal injection of KH631 in bilateral eyes
| Animal ID | Predose |
4 wk postdose |
8 wk postdose |
13 wk postdose |
||||
|---|---|---|---|---|---|---|---|---|
| NAb blockade (%) | Result | NAb blockade (%) | Result | NAb blockade (%) | Result | NAb blockade (%) | Result | |
| 1F001 | 16.59 | N | 16.51 | N | / | / | / | / |
| 1F002 | 4.62 | N | / | / | 91.55 | P | / | / |
| 1F003 | 51.27 | P | / | / | / | / | 63.06 | P |
| 1M001 | 91.59 | P | 88.91 | P | / | / | / | / |
| 1M002 | 36.47 | N | / | / | 57.53 | P | / | / |
| 1M003 | −3.16 | N | / | / | / | / | 100.1 | P |
N, negative; P, positive.