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. 2023 Oct 17;42(46):3371–3384. doi: 10.1038/s41388-023-02859-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Timeline of important discoveries in the research field of p63 in epithelial tissues. B Schematic representation of the alternative promoters generating the TAp63 and ΔNp63 isoforms along with structural features and domains of the p63 protein variants. p63 protein are shown: TA transactivating domain, DBD DNA-binding domain, OD oligomerization domain, SAM sterile alpha motif, TID trans-inhibitory domain. C The differential expression pattern of TAp63 and ΔNp63 variants (α, β, and γ) in different normal tissues (Data source, GTex portal).