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. 2023 Oct 17;42(46):3371–3384. doi: 10.1038/s41388-023-02859-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Distinct expression levels of the p63 protein in different tumor tissues (The Human Protein Atlas, https://www.proteinatlas.org/ENSG00000073282-TP63/pathology). B The ΔNp63 isoform plays a crucial role in regulating various signaling pathways implicated in CSC stemness regulation, particularly in breast and SCC cancers. C p63 regulates ALDH1A1 in the context of prostate cancer, in which p63 affects CSC stemness. D TAp63 modulates the expression of specific Hippo pathway components to regulate the stemness of CSCs in breast cancer.