Fig. 2. Top SNPs at the HLA-B and ERAP1 loci across eight cohorts.
A A forest plot depicting the association details for HLA-B top risk variant rs543685299 in each of the eight cohorts tested and including all ancestries. B A forest plot depicting the association details for the top ERAP1 protective intronic variant rs3198304 in the eight cohorts tested and including all ancestries. A meta-analysis result combining all cohorts is the lowest row (bold), meta-analysis OR is presented by a red diamond. Center points represent odds ratios as estimated by approximate Firth logistic regression, with errors bars representing 95% confidence intervals. P values are uncorrected and reflect two-sided tests. Numbers below the cases and controls columns represent counts of individuals with homozygote reference, heterozygote and homozygous alternative genotypes, respectively.