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. 2023 Nov 10;14(11):730. doi: 10.1038/s41419-023-06259-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A KYSE150 cells were treated with NR, U0126, or a combination, and cell proliferation was detected by colony formation assay. B KYSE150 cells were treated with NR, U0126, or a combination, and cell migration and invasion were examined by Transwell assays. C Representative images of tumors excised from mice injected with PBS, NR, U0126, or a combination of NR and U0126. D, E The volume and weight of each tumor were measured during the indicated periods. F Schematic representation of the potential mechanism of USP4 in ESCC progression. *P < 0.05, ***P < 0.001.