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. 2023 Nov 10;13:19610. doi: 10.1038/s41598-023-46927-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative images of RICTOR-amplified/non-amplified cases by FISH (a) and the high/low expressions of IHC stainings (b) in the studied tumour samples. The presented squamous cell carcinoma of the lung (case #36) showed RICTOR amplification with high Rictor and high Phospho-Ser473-Akt protein expressions. The other tubo-ovarian high-grade serous carcinoma (case #23) represents no amplification without increased Rictor and Phospho-Ser473-Akt expressions.