Table 5.
Compare the results of two publicly available databases (http://cnvintegrate.cgm.ntu.edu.tw and http://cbioportal.org) with our NGS results of RICTOR alteration frequencies in the studied human cancer tissues.
| Tumour types | CNVintegrate (n = N/A) | cBioPortal | NGS result of our studied cases (n = 420) | ||
|---|---|---|---|---|---|
| MSK MetTropism (n = 25,775) | TCGA PanCancer Atlas studies (n = 10,967) | ||||
| Breast tumours | 1.40% | 0.27% | 1.12% | 0.48% | |
| Central nervous system tumours | 0.09% | – | 0.20% | 1.43% | |
| Digestive system tumours | Hepatobiliary tract | 5.31% | 0.22% | 0.82% | 0.24% |
| Large intestine | 0.52% | 1.87% | 0.68% | 0.95% | |
| Oesophagus | 7.31% | 2.32% | 6.61% | – | |
| Pancrease | 0.24% | 0.40% | 0.54% | 1.19% | |
| Stomach | 4.99% | 1.24% | - | 0.24% | |
| Female genital tumours | Cervix | 7.03% | - | 5.12% | 0.48% |
| Endometrium | 1.34% | 0.30% | 2.42% | 0.24% | |
| Ovary | 3.58% | 0.59% | 5.24% | 0.95% | |
| Head and neck tumours | 5.33% | 0.73% | 4.06% | 0.48% | |
| Skin tumours | 2.04% | 0.79% | 2.45% | – | |
| Soft tissue and bone tumours | 4.73% | 3.02% | 4.74% | 0.95% | |
| Thoracic tumours | Lung | 11.64% | 6.80% | 9.42% | 0.95% |
| Pleural mesothelioma | 1.85% | 0.41% | – | – | |
| Tumours of endocrine organs | Adrenal gland | 1.87% | – | 5.62% | 0.24% |
| Thyroid | 0.20% | – | – | – | |
| Tumours of haematopoietic and lymphoid tissues | 0.12% | – | 2.08% | – | |
| Urinary and male genital tumours | Bladder | 6.21% | 1.64% | 5.39% | – |
| Kidney | 0.29% | – | 0.39% | – | |
| Prostate | 0.19% | 0.32% | 0.41% | – | |
N/A not available.