Table 3.
Membership assignment of three module-based PRSs in previously defined cognitive subtypes of AD in ADNI
| Source of PRS | Executive Functioning ST | Language ST | Memory ST | Visuospatial Functioning ST | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Genome-wide PRS (gwPRS) | ||||||||
| NP | 0.99 (0.93–1.0) | 0.69 | 0.99 (0.95–1.0) | 0.43 | 1.00 (0.99–1.00) | 0.57 | 1.00 (0.97–1.00) | 0.75 |
| NFT | 1.00 (0.91–1.10) | 0.98 | 0.99 (0.93–1.01) | 0.74 | 1.01 (1.00–1.11) | 0.04 | 0.96 (0.91–1.01) | 0.09 |
| AD-Risk | 1.01 (0.93–1.10) | 0.65 | 0.97 (0.91–1.00) | 0.24 | 1.00 (1.00–1.10) | 0.08 | 0.96 (0.91–1.00) | 0.07 |
| Module-based PRS (mbPRSs) | ||||||||
| M6 | 0.37 (0.04–3.60) | 0.39 | 5.50 (1.50–20.0) | 0.009 | 0.97 (0.44–2.20) | 0.95 | 0.88 (0.28–2.80) | 0.83 |
| M9 | 0.95 (0.34–2.60) | 0.92 | 0.81 (0.42–1.50) | 0.51 | 1.20 (0.84–1.80) | 0.29 | 1.91 (1.11–3.31) | 0.04 |
| M12 | 1.10 (0.78–1.50) | 0.66 | 0.92 (0.75–1.10) | 0.40 | 1.00 (0.92–1.20) | 0.56 | 1.00 (0.87–1.20) | 0.76 |
OR: odds ratio; CI: 95% confidence interval; P: P value. NP: neuritic plaques; NFT: neurofibrillary tangles. Cognitively-defined AD subtypes (ST) in ADNI have been previously defined [9]. Bold values with significance at P<0.01 and OR>1.0 indicate these modules are likely members of the corresponding cognitively-defined subtypes.