Figure 10.

(A) CLSM images of FLS uptake of DAPI-labeled and C6-labeled nanoparticles. DAPI stained the nucleus and C6 stained the cytoplasm. (B) SEM images of Tet-6 s-NPs (CaCO₃)/PG-MNs. (C) CLSM images of penetration of sulforhodamine B-labeled 6 s-NPs (CaCO₃)/PG-MNs into the skin. (D) Sulforhodamine B-labeled 6 s-NPs (CaCO₃)/PG-MNs-treated skin, OCT embedded and liquid nitrogen freezer, sliced horizontally with the skin surface, supporting the results of the puncture performance study. (E) The appearance of paw swelling. (F) Micrographs of H&E-stained pathological sections of ankle joints from AA-bearing rats treated with the test preparations. (G) Micrographs of immunohistochemical sections of VEGF and MVD in synovial tissues from AA-bearing rats. (H) Irritation response of the skin in AA-bearing rats before and after treatment with the test preparations. Reprinted with the permission from Ref. 200. Copyright © 2022 Elsevier.