| 1 New fractures |
5 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.1 Yigu capsule plus calcium versus placebo plus calcium (6 months) |
1 |
140 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.06 [0.00, 1.00] |
| 1.2 Xianlinggubao capsule (low‐dose) plus calcium and vitamin D versus placebo plus calcium and vitamin D (12 months) |
1 |
120 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.33 [0.01, 8.02] |
| 1.3 Xianlinggubao capsule (high‐dose) plus calcium and vitamin D versus placebo plus calcium and vitamin D (12 months) |
1 |
116 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.36 [0.01, 8.58] |
| 1.4 Bushen Zhuanggu granules plus calcium and vitamin D versus placebo granules plus calcium and vitamin D (5 years) |
1 |
155 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.44 [0.13, 1.43] |
| 1.5 Kanggusong soup plus Caltrate versus Caltrate (3 months) |
1 |
75 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.22 [0.01, 5.34] |
| 1.6 Zhuangguqiangjin tablet and Shujinbogu tablet plus calcitonin versus calcitonin (12 months) |
1 |
90 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 2 Bone mineral density (BMD) |
43 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 2.1 Gushen decoction plus Caltrate and Alfacalcidol versus Caltrate and Alfacalcidol (BMD of lumbar spine, 6 months) |
1 |
64 |
Mean Difference (IV, Random, 95% CI) |
0.06 [0.01, 0.11] |
| 2.2 Jiarong tablet plus Caltrate versus Caltrate (BMD of lumbar spine, 6 months) |
1 |
41 |
Mean Difference (IV, Random, 95% CI) |
0.04 [‐0.05, 0.14] |
| 2.3 Ziyin Bushen Zhuanggu prescription plus Caltrate and calcitonin versus Caltrate plus calcitonin (BMD of lumbar spine, 8 months) |
1 |
45 |
Mean Difference (IV, Random, 95% CI) |
0.14 [0.08, 0.20] |
| 2.4 Zhuanggu capsule plus Caltrate versus Caltrate (BMD of lumbar spine, 6 months) |
1 |
60 |
Mean Difference (IV, Random, 95% CI) |
0.01 [0.00, 0.02] |
| 2.5 Antai capsule plus Caltrate versus Caltrate (BMD of lumbar spine, 6 months) |
1 |
128 |
Mean Difference (IV, Random, 95% CI) |
0.04 [‐0.00, 0.08] |
| 2.6 Bushen Zhuanggutang plus Caltrate versus Caltrate (BMD of lumbar spine, 6 months) |
1 |
60 |
Mean Difference (IV, Random, 95% CI) |
0.14 [0.06, 0.22] |
| 2.7 Zishen prescription plus Caltrate and calcitonin versus Caltrate plus calcitonin (BMD of lumbar spine, 8 months) |
1 |
45 |
Mean Difference (IV, Random, 95% CI) |
0.14 [0.08, 0.20] |
| 2.8 Guilu Erxiantang plus calcium carbonate tablet versus calcium carbonate tablet (BMD of lumbar spine, 6 months) |
1 |
85 |
Mean Difference (IV, Random, 95% CI) |
0.03 [‐0.03, 0.09] |
| 2.9 Guben Zhuanggu capsules plus Caltrate versus Caltrate (BMD of lumbar spine, 6 months) |
1 |
60 |
Mean Difference (IV, Random, 95% CI) |
0.03 [0.01, 0.05] |
| 2.10 Migu tablet plus Caltrate versus Caltrate (BMD of Lumbar spine, 12 months) |
1 |
44 |
Mean Difference (IV, Random, 95% CI) |
0.08 [0.07, 0.09] |
| 2.11 Shugan zishen huoxue tang plus Caltrate and alendronate sodium versus Caltrate plus alendronate sodium (BMD of lumbar spine, 6 months) |
1 |
42 |
Mean Difference (IV, Random, 95% CI) |
0.12 [0.08, 0.16] |
| 2.12 Bushen Yangxue tang plus Caltrate versus Caltrate (BMD of lumbar spine, 6 months) |
1 |
60 |
Mean Difference (IV, Random, 95% CI) |
0.02 [‐0.02, 0.06] |
| 2.13 Bushen Kangsong pill plus calcium carbonate tablets versus calcium carbonate tablets (BMD of lumbar spine, 6 months) |
1 |
84 |
Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.03, 0.04] |
| 2.14 Gusongbao granule plus compound calcium amino acid chelate capsule versus placebo granule plus compound calcium amino acid chelate capsule (BMD of lumbar spine, 6 months) |
1 |
96 |
Mean Difference (IV, Random, 95% CI) |
‐0.01 [‐0.07, 0.05] |
| 2.15 Qianggu capsule plus alendronate versus alendronate (BMD of lumbar spine, 6 months) |
1 |
80 |
Mean Difference (IV, Random, 95% CI) |
0.08 [0.03, 0.12] |
| 2.16 Xianlinggubao capsule plus Caltrate versus Caltrate (BMD of lumbar spine, 12 months) |
1 |
68 |
Mean Difference (IV, Random, 95% CI) |
0.30 [0.25, 0.35] |
| 2.17 Xianlinggubao capsule plus salmon calcitonin and Caltrate versus salmon calcitonin plus Caltrate (BMD of lumbar spine, 3 months) |
1 |
107 |
Mean Difference (IV, Random, 95% CI) |
0.03 [‐0.03, 0.09] |
| 2.18 Xianlinggubao capsule plus alendronate versus alendronate (BMD of lumbar spine, 6 months) |
1 |
104 |
Mean Difference (IV, Random, 95% CI) |
0.06 [0.03, 0.09] |
| 2.19 Xianlinggubao capsule plus vitamin D3 and calcium amino acid chelate versus vitamin D3 and calcium amino acid chelate (BMD of lumbar spine, 48 weeks) |
1 |
112 |
Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.03, 0.06] |
| 2.20 Xianlinggubao capsule plus Caltrate versus Caltrate (BMD of lumbar spine, 12 months) |
1 |
136 |
Mean Difference (IV, Random, 95% CI) |
0.31 [0.28, 0.34] |
| 2.21 Xianlinggubao capsule plus compound calcium amino acid chelate capsule versus compound calcium amino acid chelate capsule (BMD of lumbar spine, 6 months) |
1 |
106 |
Mean Difference (IV, Random, 95% CI) |
0.18 [0.14, 0.22] |
| 2.22 Jiangu granule plus compound calcium amino acid chelate capsule versus placebo granule plus compound calcium amino acid chelate capsule (BMD of lumbar spine, 6 months) |
1 |
96 |
Mean Difference (IV, Random, 95% CI) |
0.04 [‐0.02, 0.10] |
| 2.23 Jinwugutong capsules plus calcium versus placebo plus calcium (BMD of lumbar spine, 6 months) |
1 |
120 |
Mean Difference (IV, Random, 95% CI) |
0.11 [0.07, 0.15] |
| 2.24 Xuduanzhuanggu capsule plus calcium tablet versus placebo plus calcium tablet (BMD of lumbar spine, 6 months) |
1 |
480 |
Mean Difference (IV, Random, 95% CI) |
0.02 [‐0.01, 0.05] |
| 2.25 Chinese medicine Bushenhuoxue recipe plus conventional western medicine versus conventional western medicine (BMD of lumbar spine, 3 months) |
1 |
57 |
Mean Difference (IV, Random, 95% CI) |
0.16 [0.09, 0.22] |
| 2.26 Gusongbao granule plus calcium tablet versus placebo plus calcium tablet (BMD of lumbar spine, 6 months) |
1 |
240 |
Mean Difference (IV, Random, 95% CI) |
‐0.01 [‐0.05, 0.03] |
| 2.27 Shengsuiyin recipe plus Caltrate versus Caltrate (BMD of Lumbar spine, 12 months) |
1 |
144 |
Mean Difference (IV, Random, 95% CI) |
0.31 [0.28, 0.34] |
| 2.28 Yigu capsule plus calcium versus placebo plus calcium (BMD of lumbar spine, 6 months) |
1 |
140 |
Mean Difference (IV, Random, 95% CI) |
0.08 [0.04, 0.12] |
| 2.29 Chinese medicine (combination of 10 herbs) plus tamoxifen and Caltrate versus tamoxifen and Caltrate (BMD of lumbar spine, 3 months) |
1 |
120 |
Mean Difference (IV, Random, 95% CI) |
0.10 [0.06, 0.14] |
| 2.30 Zhuangguqiangjin tablet and Shujinbogu tablet plus calcitonin versus calcitonin (BMD of lumbar spine, 12 months) |
1 |
90 |
Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.04, 0.06] |
| 2.31 Migu tablet plus compound calcium amino acid chelate capsule versus compound calcium amino acid chelate capsule (BMD of lumbar spine, 6 months) |
1 |
107 |
Mean Difference (IV, Random, 95% CI) |
0.17 [0.14, 0.20] |
| 2.32 Huangqi plus Caltrate versus Caltrate (BMD of lumbar spine, 6 months) |
1 |
36 |
Mean Difference (IV, Random, 95% CI) |
0.06 [0.01, 0.11] |
| 2.33 Jiarong tablet plus Caltrate versus Caltrate (BMD of femoral neck, 6 months) |
1 |
41 |
Mean Difference (IV, Random, 95% CI) |
0.09 [0.02, 0.15] |
| 2.34 Antai capsule plus Caltrate versus Caltrate (BMD of femoral neck, 6 months) |
1 |
128 |
Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.02, 0.04] |
| 2.35 Xianlinggubao capsule plus Caltrate versus Caltrate (BMD of femoral neck, 12 months) |
1 |
68 |
Mean Difference (IV, Random, 95% CI) |
0.3 [0.25, 0.35] |
| 2.36 Guben Zhuanggu capsules plus Caltrate versus Caltrate (BMD of femoral neck, 6 months) |
1 |
60 |
Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.01, 0.02] |
| 2.37 Migu tablet plus Caltrate versus Caltrate (BMD of femoral neck, 12 months) |
1 |
44 |
Mean Difference (IV, Random, 95% CI) |
0.09 [0.08, 0.10] |
| 2.38 Qianggu capsules plus oestradiol valerate versus oestradiol valerate (BMD of femoral neck, 6 months) |
1 |
88 |
Mean Difference (IV, Random, 95% CI) |
0.03 [‐0.01, 0.07] |
| 2.39 Chinese medicine Bushenhuoxue recipe plus conventional western medicine versus conventional western medicine (BMD of femoral neck, 3 months) |
1 |
57 |
Mean Difference (IV, Random, 95% CI) |
0.17 [0.12, 0.23] |
| 2.40 Heche Dazao pill plus oyster shell calcium chewable tablets versus oyster shell calcium chewable tablets (BMD of femoral neck, 3 months) |
1 |
114 |
Mean Difference (IV, Random, 95% CI) |
0.04 [0.00, 0.07] |
| 2.41 Xianlinggubao capsule plus compound calcium amino acid chelate capsule versus compound calcium amino acid chelate capsule (BMD of femoral neck, 6 months) |
1 |
106 |
Mean Difference (IV, Random, 95% CI) |
0.26 [0.22, 0.30] |
| 2.42 Huangqi plus Caltrate versus Caltrate (BMD of femoral neck, 6 months) |
1 |
36 |
Mean Difference (IV, Random, 95% CI) |
0.07 [0.03, 0.11] |
| 2.43 Gusongbao granule plus compound calcium amino acid chelate capsule versus placebo granule plus compound calcium amino acid chelate capsule (BMD of femoral neck, 6 months) |
1 |
96 |
Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.03, 0.05] |
| 2.44 Jiangu granule plus compound calcium amino acid chelate capsule versus placebo granule plus compound calcium amino acid chelate capsule (BMD of femoral neck, 6 months) |
1 |
96 |
Mean Difference (IV, Random, 95% CI) |
‐0.02 [‐0.07, 0.03] |
| 2.45 Xuduanzhuanggu capsule plus calcium tablet versus placebo plus calcium tablet (BMD of femoral neck, 6 months) |
1 |
480 |
Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.01, 0.03] |
| 2.46 Gusongbao granule plus calcium tablet versus placebo plus calcium tablet (BMD of femoral neck, 6 months) |
1 |
240 |
Mean Difference (IV, Random, 95% CI) |
0.0 [‐0.03, 0.03] |
| 2.47 Yigu capsule plus calcium versus placebo plus calcium (BMD of femoral neck, 6 months) |
1 |
140 |
Mean Difference (IV, Random, 95% CI) |
0.04 [0.01, 0.07] |
| 2.48 Migu tablet plus compound calcium amino acid chelate capsule versus compound calcium amino acid chelate capsule (BMD of femoral neck, 6 months) |
1 |
107 |
Mean Difference (IV, Random, 95% CI) |
0.24 [0.21, 0.27] |
| 2.49 Antai capsule plus Caltrate versus Caltrate (BMD of Ward's, 6 months) |
1 |
128 |
Mean Difference (IV, Random, 95% CI) |
0.0 [‐0.03, 0.03] |
| 2.50 Migu tablet plus Caltrate versus Caltrate (BMD of Ward's, 12 months) |
1 |
44 |
Mean Difference (IV, Random, 95% CI) |
0.09 [0.08, 0.10] |
| 2.51 Qianggu capsule plus alendronate versus alendronate (BMD of Ward's, 6 months) |
1 |
80 |
Mean Difference (IV, Random, 95% CI) |
0.05 [0.02, 0.07] |
| 2.52 Xianlinggubao capsule plus alendronate versus alendronate (BMD of Ward's, 6 months) |
1 |
104 |
Mean Difference (IV, Random, 95% CI) |
0.04 [0.02, 0.06] |
| 2.53 Gusongbao granule plus compound calcium amino acid chelate capsule versus placebo granule plus compound calcium amino acid chelate capsule (BMD of Ward's, 6 months) |
1 |
96 |
Mean Difference (IV, Random, 95% CI) |
‐0.01 [‐0.06, 0.04] |
| 2.54 Xianlinggubao capsule plus compound calcium amino acid chelate capsules versus compound calcium amino acid chelate capsules (BMD of Ward's, 6 months) |
1 |
106 |
Mean Difference (IV, Random, 95% CI) |
0.23 [0.19, 0.27] |
| 2.55 Migu tablet plus compound calcium amino acid chelate capsules versus compound calcium amino acid chelate capsules (BMD of Ward's, 6 months) |
1 |
107 |
Mean Difference (IV, Random, 95% CI) |
0.28 [0.24, 0.32] |
| 2.56 Jiangu granule plus compound calcium amino acid chelate capsule versus placebo granule plus compound calcium amino acid chelate capsule (BMD of Ward's, 6 months) |
1 |
96 |
Mean Difference (IV, Random, 95% CI) |
‐0.01 [‐0.06, 0.04] |
| 2.57 Xuduanzhuanggu capsule plus calcium tablet versus placebo plus calcium tablet (BMD of Ward's, 6 months) |
1 |
480 |
Mean Difference (IV, Random, 95% CI) |
0.02 [‐0.00, 0.04] |
| 2.58 Gusongbao granule plus calcium tablet versus placebo plus calcium tablet (BMD of Ward's, 6 months) |
1 |
240 |
Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.02, 0.04] |
| 2.59 Yigu capsule plus calcium versus placebo plus calcium (BMD of Ward's, 6 months) |
1 |
140 |
Mean Difference (IV, Random, 95% CI) |
0.04 [0.00, 0.08] |
| 2.60 Antai capsule plus Caltrate versus Caltrate (BMD of trochanter, 6 months) |
1 |
128 |
Mean Difference (IV, Random, 95% CI) |
0.03 [0.00, 0.06] |
| 2.61 Migu tablet plus Caltrate versus Caltrate (BMD of trochanter, 12 months) |
1 |
44 |
Mean Difference (IV, Random, 95% CI) |
0.15 [0.14, 0.16] |
| 2.62 Xuduanzhuanggu capsule plus calcium tablet versus placebo plus calcium tablet (BMD of trochanter, 6 months) |
1 |
480 |
Mean Difference (IV, Random, 95% CI) |
0.0 [‐0.02, 0.02] |
| 2.63 Migu tablet plus compound calcium amino acid chelate capsules versus compound calcium amino acid chelate capsules (BMD of trochanter, 6 months) |
1 |
107 |
Mean Difference (IV, Random, 95% CI) |
0.12 [0.07, 0.17] |
| 2.64 Xianlinggubao capsule plus compound calcium amino acid chelate capsules versus compound calcium amino acid chelate capsules (BMD of trochanter, 6 months) |
1 |
106 |
Mean Difference (IV, Random, 95% CI) |
0.13 [0.08, 0.18] |
| 2.65 Gusongbao granule plus calcium tablet versus placebo plus calcium tablet (BMD of trochanter, 6 months) |
1 |
240 |
Mean Difference (IV, Random, 95% CI) |
0.0 [‐0.03, 0.03] |
| 2.66 Yigu capsule plus calcium versus placebo plus calcium (BMD of trochanter, 6 months) |
1 |
140 |
Mean Difference (IV, Random, 95% CI) |
0.02 [‐0.02, 0.06] |
| 2.67 Gushukang granule plus Calcium carbonate with vitamin D chewable tablets versus Calcium carbonate with vitamin D chewable tablets (BMD of hip bone, 6 months) |
1 |
42 |
Mean Difference (IV, Random, 95% CI) |
0.15 [0.11, 0.19] |
| 2.68 Jinwugutong capsules plus calcium versus placebo plus calcium (BMD of hip bone, 6 months) |
1 |
120 |
Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.02, 0.04] |
| 2.69 Gengnian Anyi tablet plus Caltrate versus Caltrate (BMD of distal radius, 6 months) |
1 |
42 |
Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.06, 0.08] |
| 2.70 Shangke Yishen Zhuanggu pill plus Caltrate and calcitonin versus Caltrate and calcitonin (BMD of lumbar spine, 3 months) |
1 |
300 |
Mean Difference (IV, Random, 95% CI) |
0.04 [0.03, 0.05] |
| 2.71 Bushenhuoxue therapy plus calcium carbonate tablets and alfacalcidol versus calcium carbonate tablets and alfacalcidol (BMD of lumbar spine, 3 months) |
1 |
80 |
Mean Difference (IV, Random, 95% CI) |
‐0.01 [‐0.04, 0.02] |
| 2.72 Gukang tablet plus oyster shell calcium chewable tablets and vitamin A and D capsules versus oyster shell calcium chewable tablets and vitamin A and D capsules (BMD of lumbar spine, for 3 months) |
1 |
80 |
Mean Difference (IV, Random, 95% CI) |
0.24 [0.14, 0.34] |
| 2.73 Liuwei Dihuang pills plus Caltrate versus Caltrate (BMD of lumbar spine, 6 months) |
1 |
72 |
Mean Difference (IV, Random, 95% CI) |
0.05 [0.02, 0.08] |
| 2.74 Yiyuanjiangu decoction plus calcitonin and calcium carbonate tablet versus calcitonin and calcium carbonate tablet (BMD of lumbar spine,3 months) |
1 |
120 |
Mean Difference (IV, Random, 95% CI) |
0.02 [‐0.01, 0.05] |
| 2.75 Yiyuanjiangu decoction plus calcitonin and calcium carbonate tablet versus calcitonin and calcium carbonate tablet (BMD of femoral neck, 3 months) |
1 |
120 |
Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.01, 0.03] |
| 2.76 Yiyuanjiangu decoction plus calcitonin and calcium carbonate tablet versus calcitonin and calcium carbonate tablet (BMD of trochanter, 3 months) |
1 |
120 |
Mean Difference (IV, Random, 95% CI) |
0.02 [0.01, 0.04] |
| 2.77 Yishen Zhuanggu decoction plus calcitriol soft capsule versus calcitriol soft capsule (BMD of lumbar spine, 3 months) |
1 |
100 |
Mean Difference (IV, Random, 95% CI) |
0.02 [‐0.00, 0.05] |
| 2.78 Hugu capsule plus Caltrate versus placebo capsule plus Caltrate (BMD of lumbar spine, 6 months) |
1 |
122 |
Mean Difference (IV, Random, 95% CI) |
0.03 [‐0.00, 0.06] |
| 2.79 Hugu capsule plus Caltrate versus placebo capsule plus Caltrate (BMD of Ward's, 6 months) |
1 |
122 |
Mean Difference (IV, Random, 95% CI) |
0.05 [0.02, 0.08] |
| 2.80 Bushen Qianggu Huoxue therapy plus calcium and cod liver oil versus calcium and cod liver oil (BMD of lumbar spine, 3 months) |
1 |
84 |
Mean Difference (IV, Random, 95% CI) |
0.05 [‐0.01, 0.11] |
| 2.81 Bushen Qianggu Huoxue therapy plus calcium and cod liver oil versus calcium and cod liver oil (BMD of femoral neck, 3 months) |
1 |
84 |
Mean Difference (IV, Random, 95% CI) |
0.02 [‐0.02, 0.05] |
| 2.82 Bushen Qianggu Huoxue therapy plus calcium and cod liver oil versus calcium and cod liver oil (BMD of Ward's, 3 months) |
1 |
84 |
Mean Difference (IV, Random, 95% CI) |
0.04 [0.02, 0.07] |
| 2.83 Xianlinggubao capsule (low‐dose) plus calcium and vitamin D versus placebo plus calcium and vitamin D (BMD of lumbar spine, 12 months) |
1 |
120 |
Mean Difference (IV, Random, 95% CI) |
0.0 [‐0.04, 0.04] |
| 2.84 Xianlinggubao capsule (high‐dose) plus calcium and vitamin D versus placebo plus calcium and vitamin D (BMD of lumbar spine, 12 months) |
1 |
116 |
Mean Difference (IV, Random, 95% CI) |
0.0 [‐0.03, 0.03] |
| 2.85 Xianlinggubao capsule (low‐dose) plus calcium and vitamin D versus placebo plus calcium and vitamin D (BMD of femoral neck, 12 months) |
1 |
120 |
Mean Difference (IV, Random, 95% CI) |
‐0.01 [‐0.05, 0.03] |
| 2.86 Xianlinggubao capsule (high‐dose) plus calcium and vitamin D versus placebo plus calcium and vitamin D (BMD of femoral neck, 12 months) |
1 |
116 |
Mean Difference (IV, Random, 95% CI) |
‐0.01 [‐0.05, 0.03] |
| 2.87 Bushen Zhuanggu granules plus calcium and vitamin D versus placebo granules plus calcium and vitamin D (BMD of distal radius, 5 years) |
1 |
155 |
Mean Difference (IV, Random, 95% CI) |
0.10 [0.09, 0.10] |
| 3 T score in BMD measurement |
1 |
67 |
Mean Difference (IV, Fixed, 95% CI) |
0.91 [0.57, 1.25] |
| 3.1 Erxian Yanggu decoction plus alendronate sodium tablets versus alendronate sodium tablets (T score, 6 months) |
1 |
67 |
Mean Difference (IV, Fixed, 95% CI) |
0.91 [0.57, 1.25] |
| 4 Quality of life |
1 |
80 |
Mean Difference (IV, Fixed, 95% CI) |
5.30 [3.67, 6.93] |
| 4.1 Bushenhuoxue therapy plus calcium carbonate tablets and alfacalcidol versus calcium carbonate tablets and alfacalcidol (3 months) |
1 |
80 |
Mean Difference (IV, Fixed, 95% CI) |
5.30 [3.67, 6.93] |
| 5 Symptoms including pain, muscle fatigue and limited mobility |
4 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 5.1 Heche Dazao pill plus oyster shell calcium chewable tablets versus oyster shell calcium chewable tablets (3 months) |
1 |
114 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.15 [1.01, 1.30] |
| 5.2 Xianlinggubao capsule plus salmon calcitonin and Caltrate versus salmon calcitonin plus Caltrate (3 months) |
1 |
107 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.33 [1.09, 1.61] |
| 5.3 Zhuangguqiangjin tablet and Shujinbogu tablet plus calcitonin versus calcitonin (12 months) |
1 |
82 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.01 [0.91, 1.12] |
| 5.4 Kanggusong soup plus Caltrate versus Caltrate (3 months) |
1 |
75 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.48 [1.09, 2.02] |
| 6 Oestradiol (E2) |
9 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 6.1 Gushen decoction plus Caltrate and Alfacalcidol versus Caltrate and Alfacalcidol (6 months) |
1 |
64 |
Mean Difference (IV, Random, 95% CI) |
4.54 [0.47, 8.61] |
| 6.2 Ziyin Bushen Zhuanggu prescription plus Caltrate and Calcitonin versus Caltrate plus Calcitonin (8 months) |
1 |
45 |
Mean Difference (IV, Random, 95% CI) |
23.21 [14.46, 31.96] |
| 6.3 Zhuanggu capsule plus Caltrate versus Caltrate (6 months) |
1 |
60 |
Mean Difference (IV, Random, 95% CI) |
4.06 [2.56, 5.56] |
| 6.4 Bushen Qiangshen pill plus Caltrate versus Caltrate (3 months) |
1 |
40 |
Mean Difference (IV, Random, 95% CI) |
7.60 [‐0.51, 15.71] |
| 6.5 Antai capsule plus Caltrate versus Caltrate (6 months) |
1 |
128 |
Mean Difference (IV, Random, 95% CI) |
11.0 [8.14, 13.86] |
| 6.6 Zishen prescription plus Caltrate and calcitonin versus Caltrate plus calcitonin (8 months) |
1 |
45 |
Mean Difference (IV, Random, 95% CI) |
23.21 [14.46, 31.96] |
| 6.7 Shugan zishen huoxue tang plus Caltrate and alendronate sodium tablets versus Caltrate plus alendronate sodium tablets (6 months) |
1 |
42 |
Mean Difference (IV, Random, 95% CI) |
26.99 [18.44, 35.54] |
| 6.8 Xianlinggubao capsule plus vitamin D3 and calcium amino acid chelate versus vitamin D3 and calcium amino acid chelate (48 weeks) |
1 |
112 |
Mean Difference (IV, Random, 95% CI) |
6.04 [4.61, 7.47] |
| 6.9 Yigu capsule plus calcium versus placebo plus calcium (6 months) |
1 |
140 |
Mean Difference (IV, Random, 95% CI) |
40.85 [33.61, 48.09] |
| 7 Serum calcium (Ca) |
12 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 7.1 Gushen decoction plus Caltrate and Alfacalcidol versus Caltrate and Alfacalcidol (6 months) |
1 |
64 |
Mean Difference (IV, Random, 95% CI) |
0.05 [‐0.02, 0.12] |
| 7.2 Gushukang granule plus Calcium carbonate with vitamin D chewable tablets versus Calcium carbonate with vitamin D chewable tablets (6 months) |
1 |
42 |
Mean Difference (IV, Random, 95% CI) |
‐0.01 [‐0.09, 0.07] |
| 7.3 Zhuanggu capsule plus Caltrate versus Caltrate (6 months) |
1 |
60 |
Mean Difference (IV, Random, 95% CI) |
0.01 [‐0.07, 0.09] |
| 7.4 Antai capsule plus Caltrate versus Caltrate (6 months) |
1 |
128 |
Mean Difference (IV, Random, 95% CI) |
‐0.03 [‐0.09, 0.03] |
| 7.5 Jinwugutong capsules plus calcium versus placebo plus calcium (6 months) |
1 |
120 |
Mean Difference (IV, Random, 95% CI) |
‐0.05 [‐0.11, 0.01] |
| 7.6 Xianlinggubao capsule plus salmon calcitonin and Caltrate versus salmon calcitonin plus Caltrate (3 months) |
1 |
107 |
Mean Difference (IV, Random, 95% CI) |
0.03 [‐0.09, 0.15] |
| 7.7 Bushenyiqihuoxue soup plus tamoxifen and Caltrate versus tamoxifen and Caltrate (3 months) |
1 |
120 |
Mean Difference (IV, Random, 95% CI) |
0.37 [0.32, 0.42] |
| 7.8 Yigu capsule plus calcium versus placebo plus calcium (6 months) |
1 |
140 |
Mean Difference (IV, Random, 95% CI) |
‐0.07 [‐0.13, ‐0.01] |
| 7.9 Chinese medicine (combination of 10 herbs) plus tamoxifen and Caltrate versus tamoxifen and Caltrate (3 months) |
1 |
120 |
Mean Difference (IV, Random, 95% CI) |
0.37 [0.32, 0.42] |
| 7.10 Zhuangguqiangjin tablet and Shujinbogu tablet plus calcitonin versus calcitonin (12 months) |
1 |
90 |
Mean Difference (IV, Random, 95% CI) |
‐0.02 [‐0.10, 0.06] |
| 7.11 Huangqi plus Caltrate versus Caltrate (6 months) |
1 |
36 |
Mean Difference (IV, Random, 95% CI) |
0.28 [0.11, 0.45] |
| 7.12 Yiyuanjiangu decoction plus calcitonin and calcium carbonate tablet versus calcitonin and calcium carbonate tablet (3 months) |
1 |
120 |
Mean Difference (IV, Random, 95% CI) |
‐0.02 [‐0.06, 0.02] |
| 8 Phosphorus (P) |
10 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 8.1 Gushen decoction plus Caltrate and Alfacalcidol versus Caltrate and Alfacalcidol (6 months) |
1 |
64 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.13 [‐0.27, 0.01] |
| 8.2 Gushukang granule plus Calcium carbonate with vitamin D chewable tabletsl versus Calcium carbonate with vitamin D chewable tablets (6 months) |
1 |
42 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.02 [‐0.11, 0.07] |
| 8.3 Zhuanggu capsule plus Caltrate versus Caltrate (6 months) |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
0.01 [‐0.06, 0.08] |
| 8.4 Antai capsule plus Caltrate versus Caltrate (6 months) |
1 |
128 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.01 [‐0.23, 0.21] |
| 8.5 Jinwugutong capsules plus calcium versus placebo plus calcium (6 months) |
1 |
120 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.02 [‐0.09, 0.05] |
| 8.6 Xianlinggubao capsule plus salmon calcitonin and Caltrate versus salmon calcitonin plus Caltrate (3 months) |
1 |
107 |
Mean Difference (IV, Fixed, 95% CI) |
0.01 [‐0.12, 0.14] |
| 8.7 Yigu capsule plus calcium versus placebo plus calcium (6 months) |
1 |
140 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.03 [‐0.08, 0.02] |
| 8.8 Zhuangguqiangjin tablet and Shujinbogu tablet plus calcitonin versus calcitonin (12 months) |
1 |
90 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.02 [‐0.08, 0.04] |
| 8.9 Huangqi plus Caltrate versus Caltrate (6 months) |
1 |
36 |
Mean Difference (IV, Fixed, 95% CI) |
0.31 [0.14, 0.48] |
| 8.10 Yiyuanjiangu decoction plus calcitonin and calcium carbonate tablet versus calcitonin and calcium carbonate tablet (3 months) |
1 |
120 |
Mean Difference (IV, Fixed, 95% CI) |
0.06 [‐0.22, 0.34] |
| 9 Alkaline phosphatase (ALP) |
15 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 9.1 Gushukang granule plus Calcium carbonate with vitamin D chewable tablets versus Calcium carbonate with vitamin D chewable tablets (6 months) |
1 |
39 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.5 [‐1.70, 0.70] |
| 9.2 Zhuanggu capsule plus Caltrate versus Caltrate (6 months) |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [‐1.55, 1.55] |
| 9.3 Bushen Qiangshen pill plus Caltrate versus Caltrate (3 months) |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.31 [‐1.72, 1.10] |
| 9.4 Xianlinggubao capsule plus salmon calcitonin and Caltrate versus salmon calcitonin plus Caltrate (3 months) |
1 |
107 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.99 [‐1.52, ‐0.46] |
| 9.5 Antai capsule plus Caltrate versus Caltrate (6 months) |
1 |
128 |
Mean Difference (IV, Fixed, 95% CI) |
1.28 [0.55, 2.01] |
| 9.6 Traditional Chinese capsule plus calcium gluconate versus calcium gluconate (9 months) |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
1.77 [1.20, 2.34] |
| 9.7 Jinwugutong capsules plus calcium versus placebo plus calcium (6 months) |
1 |
120 |
Mean Difference (IV, Fixed, 95% CI) |
1.01 [‐0.04, 2.06] |
| 9.8 Yigu capsule plus calcium versus placebo plus calcium (6 months) |
1 |
140 |
Mean Difference (IV, Fixed, 95% CI) |
1.73 [0.71, 2.75] |
| 9.9 Chinese medicine (combination of 10 herbs) plus tamoxifen and Caltrate versus tamoxifen and Caltrate (3 months) |
1 |
120 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.26 [‐1.64, 1.12] |
| 9.10 Zhuangguqiangjin tablet and Shujinbogu tablet plus calcitonin versus calcitonin (12 months) |
1 |
90 |
Mean Difference (IV, Fixed, 95% CI) |
0.08 [‐0.54, 0.70] |
| 9.11 Bushenyiqihuoxue soup plus tamoxifen and Caltrate versus tamoxifen and Caltrate (3 months) |
1 |
120 |
Mean Difference (IV, Fixed, 95% CI) |
3.54 [1.68, 5.40] |
| 9.12 Huangqi plus Caltrate versus Caltrate (6 months) |
1 |
36 |
Mean Difference (IV, Fixed, 95% CI) |
0.82 [0.63, 1.01] |
| 9.13 Xianlinggubao capsule plus vitamin D3 and calcium amino acid chelate versus vitamin D3 and calcium amino acid chelate (48 weeks) |
1 |
112 |
Mean Difference (IV, Fixed, 95% CI) |
10.48 [9.81, 11.15] |
| 9.14 Kanggusong soup plus Caltrate versus Caltrate (3 months) |
1 |
75 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.61 [‐3.17, ‐0.05] |
| 9.15 Yiyuanjiangu decoction plus calcitonin and calcium carbonate tablet versus calcitonin and calcium carbonate tablet (3 months) |
1 |
120 |
Mean Difference (IV, Fixed, 95% CI) |
0.31 [‐0.48, 1.10] |
| 10 Bone Gla protein (BGP) |
8 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 10.1 Zhuanggu capsule plus Caltrate versus Caltrate (6 months) |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.3 [‐4.07, ‐0.53] |
| 10.2 Traditional Chinese capsule plus calcium gluconate versus calcium gluconate (9 months) |
1 |
60 |
Mean Difference (IV, Fixed, 95% CI) |
1.23 [0.88, 1.58] |
| 10.3 Xianlinggubao capsule plus salmon calcitonin and Caltrate versus salmon calcitonin plus Caltrate (3 months) |
1 |
107 |
Mean Difference (IV, Fixed, 95% CI) |
0.56 [‐0.30, 1.42] |
| 10.4 Yigu capsule plus calcium versus placebo plus calcium (6 months) |
1 |
140 |
Mean Difference (IV, Fixed, 95% CI) |
2.60 [1.66, 3.54] |
| 10.5 Xianlinggubao capsule plus vitamin D3 and calcium amino acid chelate versus vitamin D3 and calcium amino acid chelate (48 weeks) |
1 |
112 |
Mean Difference (IV, Fixed, 95% CI) |
6.24 [5.69, 6.79] |
| 10.6 Xianlinggubao capsule plus Caltrate versus Caltrate (12 months) |
1 |
68 |
Mean Difference (IV, Fixed, 95% CI) |
1.85 [0.87, 2.83] |
| 10.7 Jinwugutong capsules plus calcium versus placebo plus calcium (6 months) |
1 |
120 |
Mean Difference (IV, Fixed, 95% CI) |
2.47 [1.44, 3.50] |
| 10.8 Huangqi plus Caltrate versus Caltrate (6 months) |
1 |
36 |
Mean Difference (IV, Fixed, 95% CI) |
0.63 [0.50, 0.76] |
| 11 Interleukin‐6 (IL‐6) |
3 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 11.1 Erxian Yanggu decoction plus alendronate sodium tablets versus alendronate sodium tablets (6 months) |
1 |
67 |
Mean Difference (IV, Fixed, 95% CI) |
‐16.18 [‐19.62, ‐12.74] |
| 11.2 Xianlinggubao capsule plus vitamin D3 and calcium amino acid chelate versus vitamin D3 and calcium amino acid chelate (48 weeks) |
1 |
112 |
Mean Difference (IV, Fixed, 95% CI) |
‐133.3 [‐139.94, ‐126.66] |
| 11.3 Kanggusong soup plus Caltrate versus Caltrate (3 months) |
1 |
75 |
Mean Difference (IV, Fixed, 95% CI) |
‐16.32 [‐31.60, ‐1.04] |
