Wang XY 2000.

Methods	Country: China Setting: hospital based Aim: to study the effects of Bushen Yigu soft extract in the treatment of osteoporosis Study design: single‐blind, placebo‐controlled, randomised controlled trial Analysis: F‐test, T‐test Loss to follow‐up: not reported
Participants	Ethnicity: Chinese 96 osteoporosis patients enrolled: 37 in herbal group, 37 in Alfacalcidol group, 22 in placebo group Inclusion criteria: Chinese diagnostic criteria for osteoporosis, BMD detected by SPA Exclusion criteria: endocrine disease
Interventions	Experimental: Bushen Yigu soft extract, 20 ml, twice a day, for 3 months Control: Alfacalcidol, 0.25 mg per day, or placebo, for 3 months
Outcomes	BMD, E2
Notes	The study was supported by a national department of traditional Chinese medicine (TCM) modernisation research project, but no declarations of interest for the primary researchers reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation	Unclear risk	No information provided
Allocation concealment	Unclear risk	No information provided
Blinding All outcomes	Low risk	Single‐blind but did not describe who was blind
Incomplete outcome data addressed All outcomes	Low risk	No missing outcome data
Free of selective reporting	Unclear risk	Not all the outcomes that were of interest in this review were reported
Free of other bias	Low risk	The study appears to be free of other sources of bias