Zhang XJ 2008.

Methods	Country: China Setting: outpatients and inpatients Aim: to observe the effects of Bushenhuoxue capsule in the treatment of senile osteoporosis Study design: randomised controlled trial Analysis: T‐test, F‐test Loss to follow‐up: not reported
Participants	Ethnicity: Chinese 60 senile osteoporosis patients enrolled: 30 in trial group, 30 in control group Inclusion criteria: Chinese diagnostic criteria for osteoporosis based on bone density levels, BMD detected by DXA Exclusion criteria: secondary osteoporosis, liver or kidney disease, disease‐affected bone metabolism
Interventions	Experimental: Bushenhuoxue capsule, 4 pills, 3 times a day, for 12 months Control: Caltrate, 600 mg, once a day and Rocaltrol, 0.5 mg, once a day, for 12 months
Outcomes	BMD, E2, IL‐6, BGP
Notes	The study was supported by the Zhejiang Provincial Department of traditional Chinese medicine (TCM) modernisation research project, but no declarations of interest for the primary researchers reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation	Unclear risk	No information provided
Allocation concealment	Unclear risk	No information provided
Blinding All outcomes	Unclear risk	Insufficient information to permit judgement of 'low risk' or 'high risk'
Incomplete outcome data addressed All outcomes	Low risk	No missing outcome data
Free of selective reporting	Unclear risk	Not all the outcomes that were of interest in this review were reported
Free of other bias	Unclear risk	No information on baseline