Table 4.
Main findings of the studies of DNAm in AEs.
| Biological sample | Subjects | Phenotype | CpG | Gene/Nearest Gene | Regression coeficient (95%CI) | P | PMID [reference] |
|---|---|---|---|---|---|---|---|
|
| |||||||
| Cord blood | 303 children recruited by a birth cohort in Manchester (UK) | Asthma-related hospitalizations or ER after the first year of life | Promoter site 1 | IL2 | 1.07 (1.01,1.14) | 0.03 | 23414538 [98] |
| Asthma/wheeze-related hospitalization after the first year of life | 1.12 (1.04,1.20) | 0.002 | |||||
|
| |||||||
| Blood | 394 children treated with ICS (57.4% Europeans, 42.6% Hispanic/Latino) | Asthma-related hospitalizations or ER in the past year despite ICS use | cg00066816 | IL12B | −3.10 (NA) | 0.002 | 31187518 [99] |
| OCS use in the past year despite ICS use. | cg00557354 | ARHGEF7 | −3.49 (NA) | 0.001 | |||
| cg04256470 | CORT, CENPS | 3.62 (NA) | <0.001 | ||||
| cg09495977 | HTRA3 | −2.42 (NA) | 0.017 | ||||
| cg12333095 | ANKRD13A | −3.48 (NA) | 0.001 | ||||
| cg13818573 | C1QL1 | −3.59 (NA) | <0.001 | ||||
| cg21589280 | DDAH1 | −3.06 (NA) | 0.003 | ||||
| cg03080985 | SH3BGRL2 | −3.07 (NA) | 0.003 | ||||
| cg04330449 | NEUROG1 | −2.64 (NA) | 0.009 | ||||
| cg05307923 | ADARB2 | −2.57 (NA) | 0.011 | ||||
| cg08724517 | MAP9 | 2.95 (NA) | 0.004 | ||||
| cg11665562 | PSMC1 | −3.25 (NA) | 0.001 | ||||
| cg14269514 | OAZ3, MRPL9 | −3.11 (NA) | 0.002 | ||||
| cg24322623 | MYOD1 | −2.96 (NA) | 0.004 | ||||
Abbreviations: CI: Confidence interval; ER: Emergency room visits; ICS: Inhaled corticosteroids; OCS: Oral steroid bursts; NA: Not available; P: P-value; UK: United Kingdom.