Table 2.
Case | Stagea | Gene Mutation | Anti-tumor | Anti-platelet | Tumor response | Neurological condition | Status | OS (mo.) | |
---|---|---|---|---|---|---|---|---|---|
1 | T3N2M0, IIIB | EGFR 19DEl | Icotinib; Lung radiotherapy | Aspirin, Clopidogrel | PR | Marked Improved | Alive | 10 | |
2 | T1N2M0, IIIA | NA | No treatment | Clopidogrel | NA | Stable | Dead | 7 | |
3 | T2N1M1, IVA |
EGFR L858R |
Gefitinib; Lung radiotherapy | Aspirin | SD | Stable | Alive | 27 | |
4 | T1N1M0, IIIB | ALK fusion | Ensartinib; Lung radiotherapy | Aspirin, Clopidogrel | PR | Marked Improved | Alive | 6 | |
5 | T1N3M1, IVB |
EGFR L858R |
Icotinib; Chemotherapy | Clopidogrel | PR | Marked Improved | Alive | 17 | |
6 | T2N3M0, IIIB | NA | No treatment | Clopidogrel | NA | Stable | Dead | 6 | |
7 | T1N2Mo, IIIA | NA | Surgery | Aspirin | NED | Improved | Alive | 48 | |
8 | T2N2M0, IIIA | Wild Type | Chemotherapy; Surgery | Aspirin, Clopidogrel | PD | Improved | Dead | 6 | |
9 | T2N1M0, IIIB | NA | No treatment | Aspirin, Clopidogrel | NA | Stable | Dead | 12 | |
10 | T2N2M0, IIIA | NA | No treatment | Clopidogrel | NA | Stable | Dead | 7 |
aAccording to the American Joint Committee on Cancer (8th edition)
Abbreviations: OS Overall survival, EGFR Epidermal growth factor receptor, ALK Anaplastic lymphoma kinase, PR Partial response, SD Stable, PD Progressive disease, NED No evidence of disease, NA Not available