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. Author manuscript; available in PMC: 2024 Aug 31.
Published in final edited form as: Cell. 2023 Aug 18;186(18):3882–3902.e24. doi: 10.1016/j.cell.2023.07.019

Figure 4. Sustained epigenetic alterations in CD34+ HSPC following severe COVID-19.

Figure 4.

(A) Overview depicting clinical groups and ATAC-seq workflow used for epigenomic profiling of CD34+ HSPC.

(B) PCA plot of HSPC ATAC-seq samples using the combined set of DAR (left). Boxplots (right) show PC1 and PC2 values for each donor across groups.

(C) Top: Normalized read density of all DAR in each clusters by groups. Each DAR (group average) is represented by a linked line across groups (top). Bottom: Cluster average of normalized DAR density score for individuals within groups.

(D) GO analysis of genes associated to cluster-specific DAR in HSPC. (p<0.05)

(E) ATAC-seq genome tracks for representative cluster-specific DAR in HSPC. Boxplots display normalized DAR densities for each donor across groups.