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. 2023 Feb 21;43(2 Suppl):95–105. doi: 10.1177/0271678X231157958

Figure 2.

Figure 2.

Effect of MB on CBF, OEF and CMRO2 in healthy human subjects (n = 8). (a, c) Effects of 0.5 mg/kg and 1 mg/kg MB on CBF and OEF respectively, shown for individual subjects. (b) group CBF means ± SEM values and regression line. Both MB doses significantly decreased CBF but no dose-dependent effect was observed. (e) CMRO2 values derived from CBF and OEF for individual participants, with both MB doses showing significant reduction from placebo (d, f) group OEF and CMRO2 means ± SEM values and regression line. MB-induced reductions relative to placebo were dose-dependent.