Table 4.

Behavioral test results in mice with prolonged hypoperfusion induced by bilateral carotid artery stenosis.

Behavioral test	Mouse age at BCAS (month)	Hypoperfusion duration	Results	Studies (reference number)
Y-maze	2–3	30 days	Spatial working memory ↓	Hou, 2015 (98)
	2–2.5	60 days	Spatial working memory ↓	Han, 2019 (61)
	2.5–3	14 and 28 days	Working memory → at day 14, ↓ at day 28	Miyanohara, 2018 (76)
	2.5	30 days	Spatial working memory↓	Washida, 2010 (70)
	2.5	28 days	Spatial working memory ↓	Miyamoto, 2013 (72)Miyamoto, 2020 (99)
	2.5	4 and 6 months	Working memory ↓ (both timepoints)	Khan, 2018 (78)
	3	14 days	Spatial working memory ↓	Dong, 2011 (100)
	3	21 days	Spatial working memory ↓	Dong, 2011 (100)
	3–4	28 days	Spatial working memory ↓	Koizumi, 2018 (79)Du, 2020 (83)
	2 and 8	14 days	Working memory of middle-aged BCAS mice↓ (compared to young BCAS mice)	Miyamoto, 2013 (29)
8-arm radial maze	2.5–3	28 days	Spatial working memory ↓Reference memory →	Chen, 2017 (56)Chen, 2019 (101)
	2.5–3	30 days	Spatial working memory↓Reference memory →	Shibata, 2007 (13)
	2.5	30 days	Spatial working memory ↓	Duan, 2009 (54)
	< 3	6 months	Spatial working memory ↓	Holland, 2015 (14)
	3–4	2 months	Spatial working memory ↓	Coltman, 2011 (25)
	4	5 months	Spatial working memory ↓	Nishio, 2010 (24)
	4–5	3 months	Spatial working memory ↓	Kitamura, 2017 (34)
Barnes maze	4	6 months	Reference memory ↓	Nishio, 2010 (24)
Water maze	2	28 days	cognitive function ↓	Park, 2019 (102)
	2–2.5	14 days	Spatial learning memory ↓	Yuan, 2017 (103)
	2.5	42 days	Spatial learning memory ↓	Iwanami, 2015 (104)
	2.5	42 days	Spatial learning memory ↓	Mogi, 2018 (105)
	3	10-14days 24-28days	Spatial learning memory ↓ exception on day 26–28	Ahn, 2016 (106)
	< 3	6 months	Spatial reference lerning and memory ↓	Holland, 2015 (14)
	3–4	1 month	Reference memory →	Coltman, 2011 (25)
	4–4.5	35 days	Reference memory ↓	Miki, 2009 (23)
	8	7 weeks	Reference memory →	Ohtomo, 2021 (52)
	9–13	7 weeks	Spatial learning memory ↓	Boehm-Strum, 2017 (37)
NORT	2	28 days	Cognitive function (30 min retention) ↓	Takase, 2021 (107)
	2–2.5	28 days	Cognitive function (6 h retention) ↓	Temma, 2017 (108)
	2–2.5	60 days	Cognitive function (1 h retention) ↓	Han, 2019 (61)
	2–3	28 days	Recognition memory (6 h retention)↓	Khan, 2015 (109)Kakae, 2019 (110)
	2.5–3	28 days	Working memory (6 h retention) ↓	Miyanohara, 2018 (76)
	2.5–3	28 days	Cognitive function (1 h retention) →	Lee, 2019 (81)
	2.5–3	40 days	Short-term (90 min) memory ↓Long-term (24 h) memory →	Patel, 2017 (57)
	3	5 weeks	Cognitive function (1 day retention) ↓	Dominguez, 2018 (75)
	3	90 days	Working memory (15 min retention) ↓	Tsai, 2015 (111)
	3–4	28 days	Cognitive function (30 min retention) ↓	Koizumi, 2018 (79)
	8	7 weeks	Cognitive function (30 min retention) ↓	Ohtomo, 2021 (52)
	9–13	7 weeks	Short-term (2 h) memory →	Boehm-Strum, 2017 (37)